“Teamwork -Focus- Perseverance and Vision for Lifelong Learning”

Research Focus/Natl-Intl. Seminar Presentations  research

Research in my laboratory encompasses  several major areas: Drug-Induced Organ Toxicity, Drug Action Mechanisms with special emphasis on Cellular Genomics:

(i) Drug and chemical-induced mechanisms of cell injury and cell death in multiple vital target organs in vivo,

Signaling mechanisms and molecular pathways of programmed (apoptotic) and unprogrammed (necrotic) cell death, and

unraveling mechanisms and exploring antitoxic/anticarcinogenic potentials of phytochemicals (natural and man-made antioxidants).

As a team, we try to dissect each and every project into smaller fragments and treat every fragment as a complex puzzle. In order to unravel mechanisms underlying each puzzle, we follow a multi-pronged approach. Specific assays include analysis of oxidative stress (production/detoxification routes of reactive oxygen and nitrogen species as well as biological reactive intermediates), DNA damage and repair pathways, cell cycle regulatory elements, intracellular redox states (antioxidants, glutathione, superoxide dismutase, catalase, glutathione peroxidase) and caspases. Prior to putting together the big-picture, we execute experiments at the organ level, cellular level, subcellular level (mitochondrial & nuclear), molecular level (microsomes, ribosomes and plasma membrane) and at the genomic level (gene expression).

Finally, we try to compose each bit of the puzzle together. This strategy has consistently guided us in the right direction to understand how xenobiotics cause cellular toxicity and helped designing protocols to combat toxicity. Although we execute experiments in the close proximity of genomics, proteomics, and toxicogenomics areas, several ground breaking discoveries have made our laboratory a world leader in the field of mechanisms of drug action, mechanistic toxicology, side effects of drugs, antotoxic and anticancer properties of phytochemicals, nutraceuticals and various cytoprotective mechanisms.









Seminars Presented Nationally-Internationally:
1. M. D. Anderson Cancer Research Center, Smithville, TX, 1988.
2. Univ. of Mississippi Medical Center, Jackson, MS, 1989.
3. Miss. Academy of Sciences, Jackson, MS, 1988 and 1989.
4. Univ. of New Mexico College of Pharmacy, ALBQ, NM, 1989, 1990, 1991.
5. Researh & Development, Procter & Gamble Company, Cincinnati, OH, 1990.
6. Rutgers Univ. JGPT- Graduate Program in Toxicol., Busch Campus, NJ, 1991.
7. Rutgers University Dept of Pharmacol & Toxicol., Busch Campus, NJ, 1993.
8. Albert Einstein School of Medicine, New York, 1992.
9. Procter & Gamble Res. & Development (Toxicology), Cincinnati, Ohio, 1991, 1992.
10. Dept of Pharmacol & Toxicology, Purdue University, West Lafayette, IN, 1992.
11. Proctor & Gamble’s Richardson Vicks R&D, USA, Connecticut, 1993.
12. National Center for Toxicological Research (NCTR), Jefferson, AR, 1993.
13. Sandoz Pharmaceuticals, NJ, 1993.
14. National Cancer Institute, Frederick, MD, 1993.
15. Ciba-Geigy Pharmaceuticals, NJ, 1993.
16. Medical Coll. of Virginia, Dept. of Pathology, Opening Grand Rounds, Jan 1994.
17. Creighton University College of Pharmacy, Toxicology Program, Omaha, NE, Spring-1995.
18. Univ. of Iowa, Coll. of Veterinary Medicine, Toxicology Prog, Ames, IA. Spring-1995.
19. University of Missouri, Colombia, MO. Spring-1995.
20. Coll of Pharmacy, University of Sciences at Philadelphia (PCPS), October, 2002.
21. Cornell University’s Graduate Prog. in Mol. Toxicology, Ithaca, NY, November, 2002.
22. European Convention Center, Luxembourg, Jan 31, 2003.
23. Institute of ArbeitPhysiologie/MaxPlank Institute, Dortmund,Germany, Feb, 2003.
24. Dept. of Biology, Long Island University, Brooklyn, NY, April-2003.
25. Division of Biological Sciences, Ravishankar University, Raipur, India, August-2003.
26. Dept of PharmaScs, Coll. of Pharmacy, Seoul National Univ., Seoul, S. Korea-Nov-2003.
27. Univ. of Colorado Health Sciences Center, College of Pharmacy, Sept-2004.
28. Wayne State Univ., Eugene & Applebaum Pharm. Sciences Program, Detroit, MI, Oct-2004.
29. Dept of Biochemistry & Molecular Biol., Univ. of Windsor, Windsor, Canada, Oct-2004.
30. Institute of Life Sciences, Choseon Pharmaceuticals, South Korea, 2006.
31. Dept of Biology, Long Island University, Brooklyn, NY 2005, 2006, 2008, 2009, 2010.
32. Manchester University School of Pharmacy, May 2012.
33. St. Francis University, Dept of Biol. & Sch. Of Osteopathic Med., FW, IN, March 2013.
34. Thomas Jefferson University School of Pharmacy, Philadelphia, PA, March 2013.
35. Manchester University at North Manchester, IN, April- May 2013.
36. Rosalind Franklin University, College of Pharmacy, No. Chicago, IL, March 2014.
37. University of Maryland- Coll. of Pharmacy at Eastern Shore, Salisbury,MD, June 2014.
38. Science Seminar at Manchester University, No. Manchester, IN, October 2015.
39. College of Pharmacy at Univ of Texas at El Paso, El Paso, TX; March 2016.
40. Campbell University College of Pharmacy, BuisCreek, North Carolina; June 2016.
41. Rutgers- The State University of New Jersey, Department of Animal Scs, New Brunswick, NJ; September 2017.
42. College of Pharmacy, University of Toledo, Toledo, Ohio; October 2017.