SEMINAL DISCOVERIES ON CELL DEATH APOCROSIS (NECRAPTOSIS OR NECROPTOSIS)

APOCROSIS/ NECRAPTOSIS/ NECROPTOSIS/ APONECROSIS

1989: First report of acetaminophen (drug)- induced site-III specific inhibition of mitochondrial respiration (reversible) and NAPQI-mediated irreversible inhibition of mitochondrial respiration; https://www.ncbi.nlm.nih.gov/pubmed/2751700

1990: First report of acetaminophen (drug)- induced liver cell DNA fragmentation & possibly apoptosis;
https://www.ncbi.nlm.nih.gov/pubmed/2256122

1994: First EM evidence of acetaminophen (drug)- induced liver cell apoptosis & necraptosis (aka apocrosis or necroptosis); Soc. of Toxicology Annual Meeting; The Toxicologist, Vol. 14(1), Pp. 298, Abst# 1155/ Pp. 329, Abst#1280. http://www.toxicology.org/pubs/docs/Tox/1994Tox.pdf

1995: Further EM evidence of acetaminophen (drug)- induced liver cell apoptosis & necraptosis (aka apocrosis or necroptosis); Soc. of Toxicology Annual Meeting; The Toxicologist, Vol. 15(1), Pp. 133, Abst# 707 & 708. http://www.toxicology.org/pubs/docs/Tox/1995Tox.pdf

1996: First publication with EM evidence on Acetaminophen-induced apoptosis & Necraptosis: J. of Pharmacol. Exp. Therapeutics: http://jpet.aspetjournals.org/content/279/3/1470.short

1997: Ray, S. D. et al. In Vivo abrogation of acetaminophen-induced hepatic genomic DNA fragmentation and apoptotic cell death by a novel grape seed proanthocyanidin extract GSPE. Provided further evidence of Apocrosis, Necraptosis or Necroptosis or Aponecrosis. The FASEB J. 12(5), Pp. A779 #4516, 1998. [*Above minisymposium presentation was chosen by FASEB National Program Committee for Press release]

1999: Ray, S.D. Cell Death and Apoptosis, In “General and Applied Toxicology”, Bryan Ballantyne, Timothy Marrs, and Paul Turner, (Eds), Vol. I, Chapter-9, Pp. 176-200, Stockton/McMillan Publications, 1999. [Further EM evidence of drug (acetaminophen & dimethylnitrosamine)-induced apoptosis and necraptosis in the liver in vivo.

2000: https://www.ncbi.nlm.nih.gov/pubmed/10663392

2001: https://www.ncbi.nlm.nih.gov/pubmed/11461765

2002: Annual Meeting of the Society of Toxicology held at Nashville Convention Center https://www.toxicology.org/events/am/ce/2002_ceListing.asp#pm10

2003: Apoptosis 2003 – From signaling pathways to therapeutic tools Congress at Luxembourg.
https://hum-molgen.org/meetings/meetings/1933.html

2004: http://onlinelibrary.wiley.com/doi/10.1002/biof.552210144/full

2005: https://www.sciencedirect.com/science/article/pii/B0123694000000831 [https://doi.org/10.1016/B0-12-369400-0/00083-1]

2006: http://pubs.acs.org/doi/abs/10.1021/bk-2006-0936.ch011

2006: https://link.springer.com/article/10.1007%2Fs11010-006-9235-2?LI=true

2009: Ray, SD. Et al.: “Apoptosis and Cell Death”, 3rd Edition, Vol. I, Chapter-11, Pp. 247-312, in Ballantyne, Marrs and Syversen Eds., ‘General and Applied Toxicology‘; Wylie Publishing, UK, 2009. http://onlinelibrary.wiley.com/doi/10.1002/9780470744307.gat015/abstract

2012: http://www.ncbi.nlm.nih.gov/pubmed/22272768

2014: Encyclopedia of Toxicology, V3, 2014. http://www.sciencedirect.com/science/article/pii/B9780123864543002426
[DOI: https://doi.org/10.1016/B978-0-12-386454-3.00242-6]

NUTRITION SCIENCES/ ANTITOXIC PROPERTIES OF PHYTOCHEMICALS
2015: http://www.ncbi.nlm.nih.gov/pubmed/26265154
Other Significant Discoveries:
(i) http://www.newswise.com/articles/long-island-university-professor-discovers-acetaminophen-induced-liver-damage-may-be-thwarted-by-grape-seed-extract
(ii) http://connection.ebscohost.com/c/articles/743741/purple-power
(iii) http://www.newswise.com/articles/acetaminophen-overpowers-some-cell-protecting-genes
(iv) http://www.newhope.com/supply-news-amp-analysis/polyphenols-punch-back-common-drugs
(v) http://www.ncbi.nlm.nih.gov/pubmed/11440826
(vi) http://www.earthisland.org/journal/index.php/eij/article/silent_towers_empty_skies/
(vii) http://liu.edu/Brooklyn/About/News/Campus-Press-Releases/2008/April/BK-Press-Release-Apr23-2008