SEMINAL DISCOVERIES APOCROSIS (NECRAPTOSIS OR NECROPTOSIS) & RECENT NEWS ON STUDENT SUCCESS

APOCROSIS/ NECRAPTOSIS/ NECROPTOSIS/ APONECROSIS

1989: First report of acetaminophen (drug)- induced site-III specific inhibition of mitochondrial respiration (reversible) and NAPQI-mediated irreversible inhibition of mitochondrial respiration; https://www.ncbi.nlm.nih.gov/pubmed/2751700

1990: First report of acetaminophen (drug)- induced liver cell DNA fragmentation & possibly apoptosis;
https://www.ncbi.nlm.nih.gov/pubmed/2256122

1994: First EM evidence of acetaminophen (drug)- induced liver cell apoptosis & necraptosis (aka apocrosis or necroptosis); Soc. of Toxicology Annual Meeting; The Toxicologist, Vol. 14(1), Pp. 298, Abst# 1155/ Pp. 329, Abst#1280. http://www.toxicology.org/pubs/docs/Tox/1994Tox.pdf

1995: Further EM evidence of acetaminophen (drug)- induced liver cell apoptosis & necraptosis (aka apocrosis or necroptosis); Soc. of Toxicology Annual Meeting; The Toxicologist, Vol. 15(1), Pp. 133, Abst# 707 & 708. http://www.toxicology.org/pubs/docs/Tox/1995Tox.pdf

1996: First publication with EM evidence on Acetaminophen-induced apoptosis & Necraptosis: J. of Pharmacol. Exp. Therapeutics: http://jpet.aspetjournals.org/content/279/3/1470.short

1997: Ray, S. D. et al. In Vivo abrogation of acetaminophen-induced hepatic genomic DNA fragmentation and apoptotic cell death by a novel grape seed proanthocyanidin extract GSPE. Provided further evidence of Apocrosis, Necraptosis or Necroptosis or Aponecrosis. The FASEB J. 12(5), Pp. A779 #4516, 1998. [*Above minisymposium presentation was chosen by FASEB National Program Committee for Press release]

1999: Ray, S.D. Cell Death and Apoptosis, In “General and Applied Toxicology”, Bryan Ballantyne, Timothy Marrs, and Paul Turner, (Eds), Vol. I, Chapter-9, Pp. 176-200, Stockton/McMillan Publications, 1999. [Further EM evidence of drug (acetaminophen & dimethylnitrosamine)-induced apoptosis and necraptosis in the liver in vivo.

2000: https://www.ncbi.nlm.nih.gov/pubmed/10663392

2001: https://www.ncbi.nlm.nih.gov/pubmed/11461765

2004: http://onlinelibrary.wiley.com/doi/10.1002/biof.552210144/full

2005: https://www.sciencedirect.com/science/article/pii/B0123694000000831 [https://doi.org/10.1016/B0-12-369400-0/00083-1]

2006: http://pubs.acs.org/doi/abs/10.1021/bk-2006-0936.ch011

2006: https://link.springer.com/article/10.1007%2Fs11010-006-9235-2?LI=true

2009: Ray, SD. Et al.: “Apoptosis and Cell Death”, 3rd Edition, Vol. I, Chapter-11, Pp. 247-312, in Ballantyne, Marrs and Syversen Eds., ‘General and Applied Toxicology‘; Wylie Publishing, UK, 2009. http://onlinelibrary.wiley.com/doi/10.1002/9780470744307.gat015/abstract

2012: http://www.ncbi.nlm.nih.gov/pubmed/22272768

2014: Encyclopedia of Toxicology, V3, 2014. http://www.sciencedirect.com/science/article/pii/B9780123864543002426
[DOI: https://doi.org/10.1016/B978-0-12-386454-3.00242-6]

2015: http://www.ncbi.nlm.nih.gov/pubmed/26265154
Other Significant Discoveries:
(i) http://www.newswise.com/articles/long-island-university-professor-discovers-acetaminophen-induced-liver-damage-may-be-thwarted-by-grape-seed-extract
(ii) http://connection.ebscohost.com/c/articles/743741/purple-power
(iii) http://www.newswise.com/articles/acetaminophen-overpowers-some-cell-protecting-genes
(iv) http://www.newhope.com/supply-news-amp-analysis/polyphenols-punch-back-common-drugs
(v) http://www.ncbi.nlm.nih.gov/pubmed/11440826
(vi) http://www.earthisland.org/journal/index.php/eij/article/silent_towers_empty_skies/
(vii) http://liu.edu/Brooklyn/About/News/Campus-Press-Releases/2008/April/BK-Press-Release-Apr23-2008

RESEARCH STUDENTS WIN NATIONAL AWARD

“Congratulations to two of our P2 students who were awarded Undergraduate Diversity Initiatives National level travel awards from the international professional organization ‘Society of Toxicology’ this year. They attended the national meeting held at the Baltimore Convention Center, MD in March 11- Both were chosen from a total of 36 winners nationally by the Society of Toxicology.
http://toxchange.toxicology.org/p/bl/et/blogid=0&blogaid=2216&s

Kalee and Kelvin also co-authored a poster titled “Dietary Exposure to an Admixture of Polyphenolics Significantly Reduces Dimethylnitrosamine (DMN)-Induced Carcinogenic Changes in Mouse Lungs” which received great attention at the meeting. Both did their research in my laboratory.

https://www.facebook.com/ManchesterUniversityCOP/photos/pb.148140071920569.-2207520000.1490635762./1351321844935713/?type=3&theater

Congratulations to Sipan Keshishyan, class of 2017, won the college-wide ‘Excellence in Research Award’ from MANCHESTER UNIVERSITY COLLEGE OF PHARMACY, NATURAL & HEALTH SCIENCES, May 12, 2017. He was recognized at the 2017 graduating class hooding ceremony at the Mirro Center, May 2017.