GRADUATE STUDENT THESIS SUPERVISION

GRADUATE – THESIS SUPERVISION

2012:
Ms. Ami Patel, BPharm, MS. Aliphatic alcohols may produce nephrotoxicity via oxidative stress (OS) and influence sirt1 and FOXO3a expression in vivo. Thesis data presented at the 2012 AACP meetings and 2012 SOT meetings [Currently a researcher at the Cold Spring Harbor Laboratories, LI, NY]
Biological Scs sECTION- 3rd absT from top-down:http://www.ajpe.org/doi/full/10.5688/ajpe76599
Visit Pg. 256; Abst#1190.http://www.toxicology.org/pubs/docs/Tox/2012Tox.pdf

Mr. Vivek Lawana, BPharm, MS. Aliphatic alcohols propagate oxidative stress-responsive cell death signals in the mouse liver and kidneys by perturbing expression of pro- and antiapoptotic genes. Thesis data presented at the 2012 AACP meetings and 2013 ASPET meetings[Currently a Sr. Graduate student at Iowa State University, Ames, Iowa] http://www.fasebj.org/content/26/1_Supplement/1050.11

2011
Ms. Sonia D. Pravasi, BPharm, MS. Ethanol exposure potentiates diclofenac-induced nephrotoxicity in vivo. 2011 SOT travel award winner. Thesis data presented at the 2011 SOT meetings and ASPET/FASEB meetings [Currently a Sr. Scientist at Bristol Meyers Squibb, NJ] The Toxicologist, Abst#766; Pg. 165. http://www.toxicology.org/pubs/docs/Tox/2011Tox.pdf

Ms. Shruti N. Desai, BPharm, MS. Role of Nrf2 and ARE family during ethanol-induced oxidative modulation of diclofenac-induced hepato- and nephrotoxicity. Thesis data presented at the 2011 SOT meetings/ 2011 ASPET’s Toxicology division’s best poster award contestant. [Worked at NIH-NIMD Neuroscience division/ currently at Oklahoma Medical Research Foundation] http://www.fasebj.org/content/25/1_Supplement/1087.10.short

Ms. Priyanka Patel, BPharm, MS. Apoptogenic, necrogenic and varied patho-morphological changes associated with diverse hepatotoxins. Thesis data presented at the 2013 SOT meetings[Currently clinical research professional at Weil Cornel Medical Collge, NY] The Toxicologist, Pg. 232, Abst# 1088. http://www.toxicology.org/pubs/docs/Tox/2013Tox.pdf

2009: Mr. Tejas Lahoti, BParm, MS. Acute doxorubicin-induced in vivo nephrotoxicity is associated with massive oxidative stress and an organized perturbation of mitochondria-centric pro- and anti-apoptotic genes. 2010 SOT National travel award winner. Graduated from PennState, Gary Perdew’s laboratory; Currently a regulatory Toxicologist;
http://www.ncbi.nlm.nih.gov/pubmed/22873725
[In 2013–T. Lahoti won- 1) Toxicologic and Exploratory Pathology specialty section best abstract award (1st place); 2) Comparative and Veterinary specialty section best abstract award (1st place); 3) Harihara Mehendale Association of Scientists of Indian Origin Student Award (2nd place); 4) Biotechnology specialty section best abstract award (1st place); 5) Molecular Biology specialty section student award (4th place) awards]

2009: Ms. Krina Shah, BPharm, MS, PharmD – ROS-mediated oxidative stress influence anti-apoptotic genes and Cyt c release in hyperglycemic mouse kidneys to initiate late nephropathic complications. Completed PharmD at the Western University’s College of Pharmacy, CA. Thesis data presented at the 2010 SFRBM meetings [SFRBM’s best poster award contestant] http://gradworks.umi.com/14/72/1472215.html

2009: Ms. Arun Venkatesh, BPharm, MS –Biodistribution and bioavailability of structurally and functionally diverse antitoxic and anticancer bioflavonoids in vivo. At the Louisiana State University, LA, Free Radical Biology Laboratory. GRC graduate student award winner. Thesis data presented at the 2009 Gordon res. Conf. http://gradworks.umi.com/14/70/1470850.html

2009: Ms. Amritaparna Sengupta, BPharm, MS – Modulation of CYP3A activity by dexamethasone and grape seed proanthocyanidin extract and their combinations in rat liver in vivo. Currently a junior scientist at Denderon laboratory, GRC graduate student award winner. Thesis data presented at the Godon res. Conf. meetings. http://gradworks.umi.com/14/63/1463323.html

2009: Mr. Chirag Patel, BPharm, MS, PhD (UMDNJ) – Differential expression of pro- and anti-apoptotic genes under the influence of oxidative stress during carbon tetrachloride -mediated liver injury in mice. Completed PhD at the UMDNJ’s cell biology-toxicology laboratories. [2011 ASPET’s Toxicology division’s best poster award contestant] http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/1140.3
https://search.proquest.com/openview/3e6420a145824b4c40a253a9bb9ef70d/1?pq-origsite=gscholar&cbl=18750&diss=y

2008:
Ms. Inna Khodos, BS, MS -Exposure to a proanthocyanidin mixture alongwith dimethylnitrosamine reduces nephrocarcinogenesis in male B6C3F1 mice. Currently at the Memorial Sloan Kettring Cancer Center, NY. Thesis data presented at the 2010 SOT meetings. http://books.google.com/books?id=ght3SCln3tkC&dq=inauthor:%22Inna+Khodos%22&hl=en&sa=X&ei=tVDTUtiVOYWIyAHq7oCYDg&ved=0CDAQ6wEwAA

2008:
Ms. Shruti Bhatt, B.Pharm., MS, PhD (U Miami- Miller SOM) -Modulation of pro- and anti-apoptotic genes and cell cycle regulatory elements during diclofenac-induced nephrotoxicity in female ICR mice. Currently completing PhD, at the University of Miami’s Miller School of Medicine [oncology/signaling laboratory] [2011 ASPET’s Toxicology division’s best poster award contestant]
http://search.proquest.com//docview/304996212
http://gradworks.umi.com/14/63/1463316.html

Ms. Elida Bulku, BS, MS, Pharm.D. -Modulation of pro- and anti-apoptotic genes and cell cycle regulatory elements by curcumin during acetaminophen-induced hepatotoxicity in mice. Currently a director of Pharmacy. GRC graduate student award winner/ FASEB-Experimental biology press release!
http://connection.ebscohost.com/c/articles/74536298/curcumin-exposure-modulates-multiple-pro-apoptotic-anti-apoptotic-signaling-pathways-antagonize-acetaminophen-induced-toxicity
http://books.google.com/books/about/Curcumin_Pre_exposure_in_Vivo_Prevents_A.html?id=lfyZ9BobJPIC

Ms. Jigna Parekh, B.Pharm., MS – Effects of structurally and functionally diverse group of phytochemicals on aniline hydroxylation (CYP2E1) of control and acetone-induced rat liver microsomes. GRC Graduate student travel award winner. Currently a scientist/toxicologist at EISAI Research-Based Healthcare Laboartories, NY. http://www.fasebj.org/cgi/content/meeting_abstract/22/1_MeetingAbstracts/1137.3

Mr. Mayur Parmar, B.Pharm., MS -Alteration of pro- and anti-apoptotic genes and cell cycle regulatory elements during streptozotoccin-induced diabetes and oxidative stress in the liver. Finished doctoral studies in neurotoxicology at the Duquesne University, Pittsburgh. [Currently a scientist at Weil Cornell Medical College, NY] http://scholar.google.com/citations?user=Ju3AfZgAAAAJ&hl=en
http://books.google.com/books/about/A_Triple_Bioflavonoid_Mixture_Modulates.html?id=DBJcAbD_o7oC#!

Mr. Syed Ismail, B.Pharm., MS – Modulation of expression of matrix metallo proteinases (MMPs -9, -10, & -12) during dimetylnitrosamine (DMN)-induced liver cell death. Finished PhD in toxicology at the Wayne State Univ, a post doctoral fellow at the Harvard University, Boston, MA. GRC graduate student award winner.
http://www.ncbi.nlm.nih.gov/pubmed/22441882

Ms. Jasmine Rathod, B.Pharm. – Modulation of matrix metallo proteases (MMPs) and MDM2 during acute dimethylnitrosamine (DMN)-induced nephrotoxicity in mice. Currently a scientist/toxicologist at NJ environmental toxicology Laboartories. [2011 ASPET’s Toxicology division’s best poster award contestant]
http://www.fasebj.org/cgi/content/meeting_abstract/21/6/A810-a

2006:
Mr. Nirav Patel, B.Pharm., MS. -Role of oxidative stress and caspases during Doxorubicin-Induced organ toxicites in male ICR mice. [Gordon Research Conference Graduate student Award Winner: 2005.] Completed PhD at the UMDNJ’s immuno-toxicology laboratories. GRC graduate student award winner.
http://www.sciencedirect.com/science/article/pii/S0041008X10000451

2004: Mr. Chintan Patel, R. Ph.-Potentiation of Furosemide-induced liver injury by Ethanol in male ICR mice. [SOT Natl. level graduate student travel award winner, 2004]. Currently a director of Pharmacy; Regulatory pharmacist. SOT travel award winner.

2003: Mr. Santosh Phadke, MS, R. Ph. -Modulation of Ethanol-Potentiated Acetaminophen-induced apoptotic and necrotic death of liver cells in mouse liver”. [SOT National level graduate student travel award winner, 2003, and Gordon Research Conference Graduate student Award Winner: Cancer Chemotherapy” 2001] Currently a Regional manager Pharmacy chain stores. SOT travel award winner. GRC graduate student award winner.

2002: Mr. Jimmy Rotolo, BS, MS, Ph.D. -Modulation of Acetaminophen-induced apoptotic and necrotic death of liver cells in Streptozotocin-induced diabetic mouse liver”. [Gordon Research Conference Graduate student Award Winner for presenting research on “Free Radical Reactions”, New Hampshire/ SOT: 2002-Travel award winner] Finished PhD in hematology/oncology at the Cornell university, now Principal Scientist at ContraFect Corp., NY.

2001: Mr. Saleem Mohammad, MS, R. Ph. -Modulation of Diclofenac-induced apoptotic and necrotic death of cells in Streptozotocin-induced diabetic mouse kidneys”. [Gordon Conference Graduate student Award Winner : “Experimental and Clinical Cancer Chemotherapy”, New Hampshire] Assistant Professor of Toxicology at Medical College in Pakistan. Gordon Res. Conference graduate student award winner.

2000: Mr. Hemal Parikh, MS, R.Ph. -Effect of Long-Term Exposure of Grape Seed Extract on Dimethylnitrosamine-Induced Liver Cancer. Presented research at the American Assoc. for Can. Res., San Francisco, CA. Currently Regional manager of Pharmacy. ASPET best poster award contestant.

2000: Mr. Eamon Hickey, BS, MS. -Diclofenac, Salicylic Acid and Chloroform-Induced nephrotoxicity: Apoptotic cell Death in Kidneys. [Recipient of Society of Toxicology’s Natl. level graduate student travel award, 2000] Currently a toxicologist/chemist in Ireland. SOT travel award winner.

1997: Mr. D. Dhruva, MS, R.Ph. -Acetaminophen-induced apoptotic and necrotic cell death: Role nitric oxide. [SOT Natl. level grad. Stu. award winner 1996, and Am. Acad. Clin. Toxicol. fellowship holder-1996] Currently a district director of Pharmacy. SOT travel award winner.

1996: Mr. Shah M. Yahya, MS, R.Ph. -Protection of acetaminophen-induced DNA fragmentation and hepatocellular death by Poly (ADP-Ribose) polymerase inhibitors. [Recipient of Society of Toxicology’s National level graduate student travel award 1995, and Arthur Sackler fellow, Long Island University] Currently a district director of Pharmacy. SOT travel award winner.
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GRADUATE THESIS COMMITTEE MEMBER AND SPECIAL RESEARCH PROJECT SUPERVISION

1) S. Sharma, R.Ph.: Modulation of apoptosis & necrosis by various alcohols in liver in vivo-1997.
2) Dr. Rafael Munoz, R.Ph.: Effects of 3-aminobenzamide in CYP450 mediated drug metabolism-1997.
3) Pardhiva, MS: Member of research committee (In Vitro Skin permeabilization of drugs)-1998.
4) Karim Aisa, R.Ph.: Member of research committee (Effect of Enarapril on SHR-SD-rats)-1998.
5) Dhiren Patel, R.Ph., PharmD.: Protection of acetaminophen-induced nephrotoxicity by grape seed extract-1999.
6) Joan Simonneli, MS: Member of thesis committee (m-RNA expression by Quercetin & Resveratrol)-1999.
7) Biren Amin, R.Ph.: Member of thesis committee. (m-RNA expression by Diadzin and Naringenin)-2000.
8) Yasir Naroo, R.Ph.: Member of thesis committee (m-RNA expression by Genistin)-2000.
9) Daniella Weng, R.Ph., MS: Member thesis committee.(Pharmacokinetics/Iontophoresis of Zidovudine)-2001.
10) Dr. Migumi Tonegawa, MD (Japan): Member of her thesis committee (PKC expression)-2001.
11) Gary Wang, R.Ph., PharmD.: Member of his thesis committee (PKC expression)-2002.
12) Ketan Thakkar, R.Ph., MS: Drug and Chemically-induced programmed cell death in spleen.
13) Dr. Shuvendu Sen, MD: Histopathological diagnosis of apoptosis in drug-exposed multiple target organs.
14) Swapan Paul, R.Ph.: Ultrastrcutural changes during NSAID-induced nephrotoxicity.
15) Paula Abdul, Pharm.D.: MNS-orange-induced cardiac changes: A biochemical study.
16) Kevin Bartnik, B.S., MS., DABT- Caspase-Independent Pathways of apoptosis.
17) Dr. Nilank Shah, MD.-Effect of Nutraceuticals on Acetaminophen-induced Liver injury.
18) Dr. Elliot Yung, MD.- Comparison of Potency of Lidocaine and Chloroprocaine in Sciatic Nerve Block.
19) Preeti Patel, B.Pharm, MS., PharmD. –Role of ischemia/reperfusion injury in drug-intoxicated liver.
20) Palak Desai, Bpharm, MS. –Role of PKC during flavonoid-induced apoptotic cell death in PC12 cells.
21) Payal Patel, BPharm., MS., PharmD. –Role antioxidants on various target organ genomes.
22) Vishal Javia, BPharm., MS. –Role of antioxidant combinations on genomic integrity of target organs.
23) Sharvani Chamrathi, BPharm, MS. –Role of apoptotic cell death during ischemia-reperfusion injury.
24) Hiren Panchal, BPharm, MS. –Role flavonoids during MPTP-induced neuronal cell death.
25) Dr. Sameer Munchala, MBBS, MD, MS. –Neuroprotective effect of pentoxyfylline on neuronal cell death.
26) Srinivas Kommjusyula, BPharm, MS – Drug-induced DNA damage and DNA repair pathways in kidneys.
27) Dwiti Pandya, BPharm, MS – Drug-induced Free radical responsive signaling pathways in the liver.
28) Rutesh Vyas, BPharm, MS –RT-PCR and DNA microarray analysis of drug-exposed yeast cells.
29) Manish Makhija, BPharm, MS – Drug-induced changes in electrophoretic patterns of nuclear proteins.
30) Sanjay Dholakia, BPharm, MS – PKC and apoptosis in PC12 cells.
31) Kavya Somapalli, BPharm, MS – Biochemical changes in the liver upon hypoglycemia and hyperglycemia.
32) Sweta Vyas, BPharm, MS- Pathological changes in the liver and kidneys during hypo- and hyperglycemia.
33) Ankita Kumar, MD, MS – Antioxidant responsive element (ARE) and oxidative stress in the lung.
34) Jinitaben Patel, BPharm, MS – Biochemical changes in the kidneys upon hypoglycemia and hyperglycemia.

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Summer High school Interns:

1. Ms. Paula Bu-Stuyvesant HS, Intel Semifinalist: Worked on anti-toxic properties of Ocimum sanctum leaf extract] http://stuyspec.com/features/558/11-stuyvesant-students-are-named-intel-finalists-and-semifinalists-at-four-stuyvesant-has-most-finalists-in-nation/ B. S. (Harvard University); Pursuing MD/PhD

2. Mr. Anup Wattamwar, MD 2001; (Rush University Medical School): Worked on Furosemide-induced DNA fragmentation in the liver.