DISEASE-STATE BASED STUDENT-CENTERED ACADEMIC ACTIVITIES

A. ADVERSE DRUG EVENTS/ADVERSE DRUG REACTIONS/PHARMACOGENOMICS

B. SIDE EFFECTS OF DRUGS

C. DIABETES/METABOLIC SYNDROME/GENOMIC ASPECTS & PREVENTION

D. GENOMIC-NONGENOMIC ASPECTS OF CANCER/ CANCER PREVENTION STRATEGIES

E. DRUG-INDUCED LIVER INJURY MECHANISMS (MOLECULAR & CELLULAR) & ITS PREVENTION STRATEGIES

F. NEURODEGENERATION MECHANISMS & ITS PREVENTION

G. CARDIOTOXICITY MECHANISMS & ITS PREVENTION

H. DRUG-INDUCED KIDNEY TOXICITY & MECHANISMS OF ITS PREVENTION

I. APOPTOSIS/NECROSIS MECHANISMS & MOLECULAR ASPECTS OF PREVENTION

J. ROLE OF ANTIOXIDANTS IN DISEASE MODULATION

K. CYTOPROTECTIVE MECHANISMS

L. ETHANOL TOXICOLOGY AND MODULATION OF ALCOHOL EFFECTS

M. PHYTOCHEMICALS/NUTRACEUTICALS & THEIR BENEFICIAL EFFECTS

N. DRUG-INDUCED OXIDATIVE STRESS AND FREE RADICAL BIOLOGY- NEW PERSPECTIVES IN PHARMACOTHERAPY

O. ANTIOXIDANTS AND GENOMIC STABILITY

A. ADVERSE DRUG EVENTs/ADVERSE DRUG REACTIONS/PHARMACOGENOMICS

1. Ray SD, Beckett† RD, Kisor DF, Gray JP and Kiersma ME. ADRs, ADEs and Side Effects of Drugs: A Bird’s Eye View. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions, Vol. 37, Pp. XXVII – XXXIX, Elsevier; 2015. http://www.sciencedirect.com/science/article/pii/S0378608015000616

2. Mechanistic and Clinical Descriptions of Adverse Drug Reactions. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions, Vol. 36, Pp. XIX – XXIV, Elsevier; 2014.http://www.sciencedirect.com/science/article/pii/B9780444634078220042

3. Definitive (Between-the-Eyes) Adverse Drug Reactions. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions, Vol. 36, Pp. XXV – XXIX, Elsevier; 2014. http://www.sciencedirect.com/science/article/pii/B9780444634078220054

B. SIDE EFFECTS OF DRUGS
1. Othumpangat, Sree (NIOSH), Noti John D (NIOSH), Ray S.D. ANTIVIRAL DRUGS. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions. Vol. 37, Chapter- 29, Pp. 329-348, Elsevier, 2015.http://www.sciencedirect.com/science/article/pii/S0378608015000033

2. Keshisyan, S., Sehdev, V., Reeves, D. and Ray S.D. CYTOSTATIC AGENTS. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions. Vol. 37, Chapter-44, Pp. 567-581, Elsevier, 2015.http://www.sciencedirect.com/science/article/pii/S037860801500046X

3. Gray JP, Ray S.D. METAL ANTAGONISTS. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions. Elsevier, Vol. 37, Chapter-23, Pp. 259-272, 2015.http://www.sciencedirect.com/science/article/pii/S0378608015000379

4. Thurston, S., Hite, G., Petry, A., and Ray S.D. ANTI-PROTOZOAL AGENTS. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions. Elsevier, Vol. 37, Chapter-28, Pp. 321-327, 2015.http://www.sciencedirect.com/science/article/pii/S0378608015000458

5. Brophy, A. and Ray S.D. Glucocorticoids. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions. Elsevier, Vol. 37, Chapter-38, 491-498, pp. 2015. http://www.sciencedirect.com/science/article/pii/S0378608015000057

6. Gray JP, Ray S.D. Metal Antagonists. In: Ray SD, Editor. Side Effects of Drugs: Annual: A worldwide yearly survey of new data in adverse drug reactions. Elsevier; 2014. Vol. 36, pp. 323–337, (ISBN: 9780444634078; Copyright © 2014 Elsevier B.V.) http://dx.doi.org/10.1016/B978-0-444-63407-8.00023-X [This is clinical case-study based review series]

C. DIABETES/METABOLIC SYNDROME

1. Parmar MS, Syed I, Gray JP, Ray SD. Curcumin, Hesperidin, and Rutin Selectively Interfere with Apoptosis Signaling and Attenuate Streptozotocin-Induced Oxidative Stress-Mediated Hyperglycemia. Curr Neurovasc Res. 2015;12(4):363-74.
http://www.ncbi.nlm.nih.gov/pubmed/26265154

2. Stohs SJ, Ray SD. Anti-diabetic and Anti-hyperlipidemic Effects and Safety of Salacia reticulata and Related Species. Phytother Res. 2015 Jul;29(7):986-95. http://www.ncbi.nlm.nih.gov/pubmed/26031882

3. Shah K, Parmar MS, Ray SD. ROS-Mediated Oxidative Stress Influence Anti-Apoptotic Genes and Cyt c Release in Hyperglycemic Mouse Kidneys to Initiate Late Nephropathic Complications. Free Radical Biology and Medicine 01/2009; 47(Supplement 1):pg:S88.
http://search.proquest.com/docview/305220500

4. Rotollo, J. A. and Ray, S. D. Streptozotocin (STZ)-induced hyperglycemia differentially modulates acetaminophen (AAP)-induced hepatic expression of cytokine levels and apoptotic cell death. Toxicological Scs. 60(1): 377, 2002.

5. Ray, S. D., Lee, H. Y., Khantsis, I., Markovics, E., Phadke, S., Mohammad, S. and R. R. Raje. Alloxan and streptozotocin-induced diabetes potentiates furosemide-induced liver-injury and liver cell apoptosis in vivo.
Toxicological Scs. 60(1): 377, 2001.

6. Mr. Saleem Mohammad, Bs, RPh, MS, Modulation of Diclofenac-induced apoptotic and necrotic death of cells in Streptozotocin-induced diabetic mouse kidneys”. Gordon res. Conf. Proceedings, 2001. [Graduate Thesis work]
http://nebula.wsimg.com/175bc0cc265de8736952c0328bf63b8c?AccessKeyId=4323AF8BFBC2D34AB0BD&disposition=0&alloworigin=1

D. CANCER/ CANCER PREVENTION MECHANISMS

1. Yang N, Ekanem NR, Sakyi CA, Ray SD. Hepatocellular carcinoma and microRNA: new perspectives on therapeutics and diagnostics. Adv Drug Deliv Rev. 2015 Jan;81:62-74. http://www.ncbi.nlm.nih.gov/pubmed/25450260

2. Lahoti TS, Patel D, Thekkemadom V, Beckett R, Ray SD. Doxorubicin-induced in vivo nephrotoxicity involves oxidative stress-mediated multiple pro- and anti-apoptotic signaling pathways. Curr Neurovasc Res. 2012 Nov;9(4):282-95. http://www.ncbi.nlm.nih.gov/pubmed/22873725

3. Syed I, Rathod J, Parmar M, Corcoran GB, Ray SD. Matrix metalloproteinase-9, -10, and -12, MDM2 and p53 expression in mouse liver during dimethylnitrosamine-induced oxidative stress and genomic injury. Mol Cell Biochem. 2012 Jun;365(1-2):351-61. http://www.ncbi.nlm.nih.gov/pubmed/22441882

4. Patel N, Joseph C, Corcoran GB, Ray SD. Silymarin modulates doxorubicin-induced oxidative stress, Bcl-xL and p53 expression while preventing apoptotic and necrotic cell death in the liver. Toxicol Appl Pharmacol. 2010 Jun 1;245(2):143-52. http://www.ncbi.nlm.nih.gov/pubmed/20144634

5. Ray SD, Parikh H, Bagchi D. Proanthocyanidin exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths. Mutat Res. 2005 Nov 11;579(1-2):81-106. http://www.ncbi.nlm.nih.gov/pubmed/16197968

6. Ray, S. Synergy of Pancratistatin and Tamoxifen in inducing apoptosis in breast cancer cells. Cancer Biology &
Therapy, Volume: 7, Issue: 3, 2008 (Invited Commentary).

7. Burchiel SW, Davis DA, Ray SD, Barton SL. DMBA induces programmed cell death (apoptosis) in the A20.1 murine B cell lymphoma. Fundam Appl Toxicol. 1993 Jul;21(1):120-4. http://www.ncbi.nlm.nih.gov/pubmed/8365579

7. Burchiel SW, Davis DA, Ray SD, Archuleta MM, Thilsted JP, Corcoran GB. DMBA-induced cytotoxicity in lymphoid and nonlymphoid organs of B6C3F1 mice: relation of cell death to target cell intracellular calcium and DNA damage. Toxicol Appl Pharmacol. 1992 Mar;113(1):126-32. http://www.ncbi.nlm.nih.gov/pubmed/1553745

8. Ray SD, Sorge CL, Kamendulis LM, Corcoran GB. Ca(++)-activated DNA fragmentation and dimethylnitrosamine-induced hepatic necrosis: effects of Ca(++)-endonuclease and poly(ADP-ribose) polymerase inhibitors in mice. J Pharmacol Exp Ther. 1992 Oct;263(1):387-94. http://www.ncbi.nlm.nih.gov/pubmed/1328612

9. Ray SD and Mehendale H. Inhibition of cell division in hepatoma cell cultures by chlordecone and carbon tetrachloride combination. Toxicol In Vitro. 1990;4(3):179-83. http://www.ncbi.nlm.nih.gov/pubmed/20837413

10. Ms. Inna Khodos, BS, MS. Exposure to a proanthocyanidin mixture along with dimethylnitrosamine reduces nephrocarcinogenesis in male B6C3F1 mice. Currently at the Memorial Sloan Kettring Cancer Center, NY. Thesis data presented at the 2010 SOT meetings. http://books.google.com/books?id=ght3SCln3tkC&dq=inauthor:%22Inna+Khodos%22&hl=en&sa=X&ei=tVDTUtiVOYWIyAHq7oCYDg&ved=0CDAQ6wEwAA

E. DRUG-INDUCED LIVER INJURY MECHANISMS/ INJURY PREVENTION MECHANISMS

1. Betharia, S., Farris, F.F., Corcoran, G. B. and Ray, SD. ‘Mechanisms of Toxicity’ In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 165-175, 2014.
http://www.sciencedirect.com/science/article/pii/B9780123864543003298

2. Ray, S. D. and G. B. Corcoran, “Apoptosis and Cell Death”, 3rd Edition, Vol. I, Chapter-11, Pp. 247-312, in Ballantyne, Marrs and Syversen Eds., ‘General and Applied Toxicology’; Wylie Publishing, UK, 2009. http://onlinelibrary.wiley.com/doi/10.1002/9780470744307.gat015/abstract;jsessionid=0ED3DFBE31C51796E98847AD77D61BEC.f03t04?userIsAuthenticated=false&deniedAccessCustomisedMessage=

3. Ray, SD et al. “Apoptosis”. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 1. Elsevier Inc., Academic Press, pp. 287–294, 2014. http://www.sciencedirect.com/science/article/pii/B9780123864543002426http://www.sciencedirect.com/science/article/pii/B0123694000000831

4. Desai, S., Farris, F.F. and Ray, SD. “Lipid Peroxidation”, In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 89–93, 2014. http://www.sciencedirect.com/science/article/pii/B9780123864543003274

5. Yang, N., Krafts, K. and Ray, SD. “Cell Proliferation”, In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 1. Elsevier Inc., Academic Press, pp. 761-765, 2014. http://www.sciencedirect.com/science/article/pii/B9780123864543002748

6. Ray, S. D. et al. Oxidative Stress is the Master Operator of Drug & Chemically-Induced Programmed & Unprogrammed Cell Death: Implications of Natural Antioxidants In Vivo. Biofactors, 21(1-4): 223-232, 2004. http://www.ncbi.nlm.nih.gov/pubmed/15630201

7. Ray, S.D., Balasubramanian, G., Reddy, C.S. and Bagchi, D. Ca2+-Calmodulin Antagonist Chlorpromazine and Poly (ADP-Ribose) Polymerase Modulators 4-Aminobenzamide and Nicotinamide Influence Hepatic Expression of Bcl-XL and P53 and Protect against acetaminophen-induced programmed and unprogrammed cell death in mice. Free Radical Biology & Medicine, 31: 277-291, 2001.http://www.ncbi.nlm.nih.gov/pubmed/11461765

8. Ray, S. D. and Jena, N. A hepatotoxic dose of acetaminophen modulates expression of bcl-2, bcl-XL, and bcl-Xs during apoptotic and necrotic death of mouse liver cells in vivo. Archives of Toxicology 73: 594-606, 2000. http://www.ncbi.nlm.nih.gov/pubmed/10663392

9. Ray, S. D. Cell Death and Apoptosis, In “General and Applied Toxicology”, Bryan Ballantyne, Timothy Marrs, and Paul Turner, (Eds), Vol. I, Chapter-9, Pp. 176-200, Stockton/McMillan Publications, 1999. http://onlinelibrary.wiley.com/doi/10.1002/9780470744307.gat015/abstract

10. Ray, S. D., Mumaw, V. R., Raje, R. R. and Fariss, M. W. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatments.J. Pharm. Exp. Thera. 279: 1470-1483, 1996.
http://www.ncbi.nlm.nih.gov/pubmed/8968373

11. Fariss, M., Jhonson, S., Walton, L. P., Mumaw, V. and Ray, S. D. Tetrahydroaminoacridine-induced ribosomal changes and inhibition of protein synthesis in rat hepatocyte suspensions. Hepatology 20: 240-246, 1994. http://www.ncbi.nlm.nih.gov/pubmed/7517383

12. Ray, S.D., Sorge, C.L., Kamendulis, L. and Corcoran, G.B. Role of Ca2+-activated DNA fragmentation in DMN-induced hepatic necrosis: Effects of Ca2+ -endonuclease and poly (ADP-Ribose) polymerase inhibitors in mice. J. Pharmacol. Exp. Therapeu. 263: 387 – 394, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1328612

12. Shen, W., Kamendulis, L., Ray, S.D. and Corcoran, G.B. Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Effects of endonuclease, DNA repair and glutathione depletion inhibitors on DNA fragmentation and cell death. Toxicol. Appl. Pharmacol. 112: 32 – 40, 1992. http://www.ncbi.nlm.nih.gov/pubmed/1957310

13. Ray, S.D. and Corcoran, G.B. Damage to the nucleus and acute cell death produced by alkylating hepatotoxins, In “Molecular Theories of Cell Life and Death”, S.Ji. Ed., Rutgers Univ. Press, NJ. Chapter -10, Pp. 384 – 400, 1991.
http://www.ncbi.nlm.nih.gov/pubmed/1561626

14. Ray, S. D., Sorge, C.L., Tavacoli, A., Raucy, J.L. and Corcoran, G.B. Extensive alteration of genomic DNA and rise in nuclear Ca2+ in vivo early after hepatotoxic acetaminophen overdose in mice. In Biological Reactive Intermediates IV. Molecular & Cellular Effects and their impact on Human Health. Adv. Exp. Med. Biol. 238: 699 – 705, 1991. [Drug Metab. Dispos.: Special Editorial Citation]. http://www.ncbi.nlm.nih.gov/pubmed/2069042

15. Shen, W., Kamendulis, L., Ray, S.D. and Corcoran, G.B. Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Correlation of nuclear Ca2+ accumulation and DNA fragmentation cell death. Toxicol. Appl. Pharmacol. 111: 242-254, 1991. http://www.ncbi.nlm.nih.gov/pubmed/1310169

16. Ray, S.D., Sorge, C.L., Raucy, J.L. and Corcoran, G.B. Early loss of large genom DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen induced liver injury. Tox. Appl. Pharm. 106: 346 – 51, 1990.
http://www.ncbi.nlm.nih.gov/pubmed/2256122

F. DRUG-INDUCED NERODEGENERATION MECHANISMS

1. Facecchia K, Fochesato LA, Ray SD, Stohs SJ, Pandey S. J Toxicol. 2011;2011:683728. doi: 10.1155/2011/683728. Oxidative toxicity in neurodegenerative diseases: role of mitochondrial dysfunction and therapeutic strategies. http://www.ncbi.nlm.nih.gov/pubmed/21785590

2. http://www.ncbi.nlm.nih.gov/pubmed/11334361

G. DRUG-INDUCED CARDIOTOXICITY MECHANISMS
1. Ray S, Phadke S, Patel C, Hackman RM, Stohs S. Short-term and long-term in vivo exposure to an ephedra- and caffeine-containing metabolic nutrition system does not induce cardiotoxicity in B6C3F1 mice. Arch Toxicol. 2005 Jun;79(6):330-40. http://www.ncbi.nlm.nih.gov/pubmed/15895207

2. Ray SD et al. Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo. http://www.ncbi.nlm.nih.gov/pubmed/15630201

3. http://www.sciencedirect.com/science/article/pii/S002751070200324X

4. http://www.ncbi.nlm.nih.gov/pubmed/11334364

H. DRUG/NSAID-INDUCED KIDNEY INJURY/ NEPHROTOXICITY MECHANISMS

1. Ray SD. Most Hepatorenal Toxins Consistently Produce Caspase-activated DNAse (CAD)-dependent DNA Ladders and Induce Apoptosis in Vivo. Presented at the AACP Annual meeting held at Seattle, July 2010. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2907861/

2. Patel, A., Lawana V. and Ray S.D. Aliphatic alcohols may produce nephrotoxicity via oxidative stress (OS) and influence sirt1 and FOXO3a expression in vivo. (In Prep-To be submitted)

3. Lawana, V., Patel A. and Ray S.D. Aliphatic alcohols propagate oxidative stress-responsive cell death signals in the mouse liver and kidneys by perturbing expression of pro- and antiapoptotic genes. (In Prep-To be submitted)

4. Desai, S., Pravasi, S. P. and Ray, S.D. Role of Nrf2 and ARE family during ethanol-induced oxidative modulation of diclofenac-induced hepato- and nephrotoxicity. (In Prep-To be submitted)

5. Lahoti T, Patel D, Thekkemadom V, Beckett R, Ray SD. Doxorubicin-Induced In Vivo Nephrotoxicity Involves Oxidative Stress-Mediated Multiple Pro- And Anti-Apoptotic Signaling Pathways. Curr Neurovasc Res. 9: 282-295, 2012. http://www.ncbi.nlm.nih.gov/pubmed/22873725

6. Hickey, E. J., Raje, R. R., Reid, V. E., S. M. Gross, and Ray, S. D. Diclofenac-Induced in vivo nephrotoxicity may involve oxidative stress mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radical Biology & Medicine, 139-152, 2001.

7. Ray, S. D., Patel, D., Wong, V., Rinkovsky, A., Bagchi, M., Raje, R. R. and Bagchi, D. Unique organoprotective properties of a novel a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine-induced spleenotoxicity, and mocap-induced neurotoxicity in mice. Res. Commu. Mol. Pathol. & Pharmacol., 107: 105-128, 2000.

I. DRUG-INDUCED APOPTOSIS/PROGRAMMED CELL DEATH MECHANISMS

1. [ Visit Medline: http://www.ncbi.nlm.nih.gov/pubmed/?term=RAY+SD+and+DRUG+INDUCED+APOPTOSIS

2. [Visit:http://www.ncbi.nlm.nih.gov/pubmed/?term=RAY+SD+and+programmed+cell+death

J. ANTIOXIDANTS/PHYTOCHEMICALS/CELLULAR REDOX STATES IN TOXICITY MECHANISMS

3. [Visit: http://www.ncbi.nlm.nih.gov/pubmed/?term=RAY+SD+and+antioxidants

K. CYTOPROTECTION MECHANISMS IN VIVO AND IN VITRO
[Visit: http://www.ncbi.nlm.nih.gov/pubmed/?term=RAY+SD+and+antioxidants+and+phytochemicals

1. http://www.ncbi.nlm.nih.gov/pubmed/22272768

2. http://www.ncbi.nlm.nih.gov/pubmed/16902808

3. http://www.ncbi.nlm.nih.gov/pubmed/11461765

4. http://www.ncbi.nlm.nih.gov/pubmed/11334364

5. http://www.ncbi.nlm.nih.gov/pubmed/11334361

6. Bagchi D, Ray SD, Patel D, Bagchi M. Protection against drug- and chemical-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract. Drugs Exp Clin Res. 2001;27(1):3-15.
http://www.ncbi.nlm.nih.gov/pubmed/11276828

7. Ray SD et al. A novel proanthocyanidin IH636 grape seed extract increases in vivo Bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch Biochem Biophys. 1999 Sep 1;369(1):42-58. http://www.ncbi.nlm.nih.gov/pubmed/10462439

8. Fariss MW, Lippman HR, Mumaw VR, Ray SD. Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbon tetrachloride, chloroform and galactosamine. Toxicol Lett. 1997 Feb 7;90(2-3):133-44. http://www.ncbi.nlm.nih.gov/pubmed/9067481

9. Ray SD etal. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatment. J Pharmacol Exp Ther. 1996 Dec;279(3):1470-83. http://www.ncbi.nlm.nih.gov/pubmed/8968373

10. Ray SD et al. Role of cellular energy status in tocopheryl hemisuccinate cytoprotection against ethyl methanesulfonate-induced toxicity. Arch Biochem Biophys. 1994 May 15;311(1):180-90.http://www.ncbi.nlm.nih.gov/pubmed/8185315

L. ETHANOL-TOXICOLOGY-ALCOHOL-INDUCED CELL INJURY AND CELL DEATH MECHANISMS

1. Patel, Ami, Lawana, V. and Ray, SD. Pro- and Antiapoptotic Gene Expression Patterns Correlate with Histopathological Changes in the Liver and Kidneys of Mice Exposed to High Doses of Aliphatic Alcohols. Toxicol. Sciences, 144(1): Pp.122, 2015 (#663).

2. Lawana, Vivek, Patel, Ami and Ray, SD. Aliphatic alcohols propagate oxidative stress-responsive cell death signals in the mouse liver and kidneys by perturbing expression of pro- and antiapoptotic genes. FASEB J, Sec. Mechanisms of Toxicity, Pp. 344 (Abst# B-139, 1050.11). http://www.fasebj.org/cgi/content/meeting_abstract/26/1_MeetingAbstracts/1050.11

3. Lawana VJ, Patel AB, DeBisschop M, Beckett RD and Ray SD. Aliphatic Alcohols Induce Hepato- and Nephrotoxicity In Vivo Primarily via Lipid Peroxidation and Genomic Instability. Poster Session-II, Biological Scs, Abst# 17, AACP Annual meeting abstract- 2012. http://www.ajpe.org/doi/full/10.5688/ajpe76599

4. *S. Phadke; R. Raje; Ray, S. D. Acute ethanol (EtOH) exposure in vivo potentiates acetaminophen (AAP)-induced hepatocellular apoptosis by modulating oxidative stress and expression of bcl-XL and p53 genes in the liver. The Toxicologist 72(1): 361 (#1752), 2003. [SOT National award winner]. http://eurekamag.com/research/034/352/034352575.php

5. Ray, S. D. Does ethanol potentiate acetaminophen-induced hepatocellular apoptosis? Fund. Appl. Toxicol. 36 (1), Pp. 247, 1997.

6. Manolas, T*, Wattamwar, A. and Ray, S. D. Induction of hepatocellular apoptosis by various alcohols in normal and Spontaneously Hypertensive-Stroke Prone rats. Fund. Appl. Toxicol. (The Toxicologist) 36 (1), Pp. 247, 1997. [*E.Merck/W.Virginia Univ. Undergrad Pharmacy award winner]

7. Ray SD et. al. Potentiation of CCl4 and CHCl3 hepatotoxicity and lethality by various alcohols. Fundam Appl Toxicol. 1990 Oct;15(3):429-40. http://www.ncbi.nlm.nih.gov/pubmed/2258008

8. Ray, S. D. and Ji, S. Hypophysis-mediated effects of alcohol on peroxidase activity of rat liver and ovaries. The Toxicologist 6 (1 ),187, 1986.

9. Ray, S. D., *Esterline, R.L. and Ji, S. Inhibition of acetaminophen-induced liver injury by glucose mannitol or ethanol: Evidence that glucose is an endogenous free radical scavenger. Fed. Proc. 45 (3) : 702, 1986. [*Travel award winner] http://www.ncbi.nlm.nih.gov/pubmed/2751700

10. Laskin, D., Ray, S. D., Pilaro A. and Ji, S. Hypophysis and Granulocyte involvement in alcohol potentiation of acetaminophen hepatotoxicity. Fed. Proc. 45 (3): 701, 1986.

11. Ray, S.D. and Ji, S. Differential action of ethanol and acetaminophen in inducing cell injury: A biochemical study. Fed. Proc. 44 (5) :1485, 1985.

M. MECHANISM-BASED BENEFICIAL EFFECTS OF DIETARY PHYTOCHEMICALS/ NUTRACEUTICALS
1. http://www.ncbi.nlm.nih.gov/pubmed/26031882

2. http://www.ncbi.nlm.nih.gov/pubmed/20716937

3. http://www.ncbi.nlm.nih.gov/pubmed/20144634

4. http://www.ncbi.nlm.nih.gov/pubmed/18386253

5. http://www.ncbi.nlm.nih.gov/pubmed/16197968

6. http://www.ncbi.nlm.nih.gov/pubmed/12628506

7. http://www.ncbi.nlm.nih.gov/pubmed/11330834

8. http://www.ncbi.nlm.nih.gov/pubmed/11758648

N. DRUG-INDUCED OXIDATIVE STRESS AND FREE RADICAL BIOLOGY- NEW PERSPECTIVES IN PHARMACOTHERAPY

1. [ Visit: http://www.ncbi.nlm.nih.gov/pubmed/?term=ray+sd+and+oxidative+stress

2. [Visit: http://www.ncbi.nlm.nih.gov/pubmed/?term=ray+sd+and+free+radicals]

O. ANTIOXIDANTS AND GENOMIC STABILITY

http://www.ncbi.nlm.nih.gov/pubmed/?term=ray+sd+and+antioxidants