Archives for July, 2009
INTERESTED IN RESEARCH IN MY LAB? YOU MUST HAVE ALL OF THE FOLLOWING:
1. GRE- 1350 OR HIGHER.
2. MUST HAVE COMPLETED 2 SEMESTERS AT LIU IN PHARM/TOX PROGRAM.
3. MUST HAVE GPA 3.5 OR HIGHER.
4. MUST HAVE COMPLETED PTM-910 & PTM-802 WITH A GRADE A- OR HIGHER!
5. SORRY! QUERRIES WILL NOT BE ENTERTAINED WITHOUT THE ABOVE REQUIREMENTS!
GRADUATE
5TH YEAR PHARM. D.: PH-430 IATROGENIC CORNER-
USE THE FOLLOWING TEXT BOOK FOR CLINICAL MANAGEMENT PORTION OF IATROGENIC DIS:
For all the Pharm.D Students (3rd Year – 6th Year) visit the Following website as frequently as you can to update your fundamentals. Need help to Navigate ! … Contact Prof.Ray.
Pharmacogenomics
http://www.accp1.org/~user/Section1_SOUND.htm
Nanotechnology
http://www.asmalldoseof.org/nanotechnology/index.php
Proteomics
http://proteome.nih.gov/archives.html
Other IATROGENIC Resources
1. http://sis.nlm.nih.gov/enviro/toxtutor.html
2. http://www.asmalldoseof.org/resources/index.php
I was more-or-less clueless what to become during my high school days, but when I began my undergraduate education, I knew I wanted to be a college professor. Later on, when I joined graduate school, I was profoundly influenced by my mentor (a Harvard-trained scientist) who taught me teaching and research both are inseparable arms of a true academician. Thus, I would go on to become a professor and a scientist. My teaching philosophy is based on multiple theories about how people learn. Students learn best by building relationships between new information and their existing body of knowledge. Such relationships provide the context that helps the student understand the deeper meaning behind the facts and cause the information to acquire a degree of relevance. However, students must be active participants in the learning process, either learning by doing or learning by listening. By applying their new knowledge to non-trivial problems, students improve their retention of the knowledge and expand their set of skills. My goal, as a teacher, is to give students the intellectual tools they need to succeed in their profession in this post-genomic era. I love teaching because it also provides an opportunity for me to share my fascination of science (by research) as well as the excitement of better understanding the world both around us and in us. Teaching is the only known instrument to disseminate innovative ideas generated via research, and the curriculum in pharmacy provides ample opportunity to experience such ideas in the classroom.
The first and foremost thing that I do in a big classroom is to show respect and care for all students, regardless of their diversity and level of interest in the course. My father always taught me that if I ever should become a teacher, “Be like the fruit tree, people throw stones at them and they throw back fruits”. This philosophy sometimes tumbles during the post-genomic era. Learning is a complex, mutual process of growth and development identified by changes in the behavior of the learner. As an educator, I see my role much more multifaceted than just delivering course materials. On day-1, I make my expectations very clear. Besides learning the course contents, I expect my students to focus on their discipline (#1), respect their colleagues and to develop better time management skills. When I teach, my primary goal is to get the students to think. A core tenet of my teaching philosophy is that I believe students learn best when they feel a sense of ownership in the learning process and enjoy learning. I achieve this by being very friendly and approachable.
I believe there is no single teaching recipe that is optimally applicable to every teacher; rather, I utilize whatever tools necessary to stimulate the maximum learning in students. This is necessary because the overall chemistry of the students, in general, varies from year to year. Students learn in different manners and at different paces. It is often difficult to motivate students particularly for large classes when interaction between teacher and students is limited. Motivation occurs when students realize what they are learning is interesting, relevant & useful for their profession. I attempt to make my presentation and lecture vivid with the help of chalk-board, recent technology, audio-visual aids and real-life examples. If I have an experience or a joke about something related to my course, I will share it with the students in class. My jokes might not always be very funny, but they always pull the students’ attention back to the lecture and makes them more at ease to ask any questions. I try to create a barrier-free atmosphere in which students feel comfortable in learning. I achieve this by being extremely patient. Some students may require more handholding than others, and I accomplish this by providing extra out-of-class time. I inevitably explain to the class why the course is structured in a certain way so that even if they do not like the course, they will understand the reasons for teaching it that way. This helps to establish a rapport with the students early in the semester.
Every student comes to the class with different needs and expectations, hence, each student needs to be treated as a unique individual. For this reason, I make an effort to get to know the names of the students. Usually I accomplish this either during a lab, recitation, or during proctoring an exam. This makes it easier to defuse anxiety to the point where the students feel comfortable asking me questions during the lecture. I try to face the class and make as much eye contact with the students as possible given my lecturing environment. I also stimulate classroom interaction by asking complicated questions. This creates a challenging environment and helps develop synthesis-level/critical thinking abilities. To recognize and reward those students who demonstrate these abilities is very satisfying.
I also make sure that when I am preparing notes for a particular topic, I am not teaching too much, or that I am not asking the students to do too much, or to perform beyond their expected level of performance. I understand that this can be very frustrating to the student. It is better for students to understand in depth on a few topics rather than to cover too many topics that they cannot benefit from at the end. Students remember their best teachers because their best teachers teach them something profound that they can carry with them throughout their life. The key is the balance; I try to maintain a balance not only in my teaching but also in my grading policies.
I believe a teacher must be a continual learner in the field of pedagogy in order to constantly culminate new and advanced technologies as well as to develop the best personalized and innovative teaching practices in order to realize his/her educational philosophy within the context of education in the 21st century. One must realize that handling post-genomic era students through pre-genomic era training could be sometimes difficult but not impossible. The research arm provides the post-genomic era mentality and vision. I sincerely believe that research and teaching both are vital to the learning process, and I have used both these skills at the LIU to become a Life-long learner and a good teacher.
Ray SD. Natural Antioxidants: Magic Bullets of the New Millenium for Hepatorenal Disorders. Symposium Session’s Title: Renal & Cardiovascular Diseases. Presented at the 1st International Congress in Cardiology held at the Everbright Convention Center, Shanghai, Dec 5-7, 2009.
Ray SD. Oxidative Stress and Cyt C Release: Crossroads of Cell Death via Mitochondria? Symposium Session’s Title: Cardiovascular Biology and Current Technologies. Presented at the 1st International Congress in Cardiology held at the Everbright Convention Center, Shanghai, Dec 5-7, 2009.
Society of Free Radical Biology & Medicine’s Annual meeting held at Indianapolis, IN, Nov 19-23, 2008. Podium Session’s Title: Antioxidants & Redox Biology.
Ehrlich-II, International Conference to honor 100th year of Nobel Prize winning ceremony of Paul Ehrlich, held at Nuremberg, Germany, October 3-5, 2008. Symposium Session’s Title: Antiinflammatory & Analgesics.
Society of Toxicology’s 2007 Annual meeting, Charlotte, NC. Poster Session’s Title: Natural Products.
Society of Free Radical Biology & Medicine’s 2004 Annual meeting, US Virgin islands. Podium Session’s Title: Antioxidants & Redox Cycling.
Society of Toxicology’s 2002 Annual meeting held in Nashville, TN. Podium session’s Title: Metals- Cadmium & Mercury.
Society of Toxicology’s 2001 Annual meeting held in San Francisco, CA. Podium Session’s Title: Apoptosis-I
Society of Toxicology’s 1997 Annual meeting held in Cincinnati, OH. Poster session’s Title: Apoptosis.
Society of Toxicology’s 1996 Annual meeting held in Los Angeles, CA. Podium session’s Title: In Vivo, Metal toxicology.
Society of Toxicology’s 1995 Annual meeting held in Baltimore, MD. Podium session’s Title: APOPTOSIS.
Ehrlich-II, International Conference to honor 100th year of Nobel Prize winning ceremony of Paul Ehrlich, held at Nuremberg, Germany, October 3-5, 2008.
International Conference on Food Factors, Meeting held at Kyoto, Japan (Dec, 2007). Presentation Title: Antioxidants micromanage oxidative stress (OS) and Cyt c release during drug or carcinogen-induced liver cell death in vivo?
Visited Choseon Pharmaceuticals, presented seminar at the Institute of Basic Science Research, Seoul, S. Korea–August 2006
APOPTOSIS-2006, Intl. Cong. held at Luxemburg, Jan-2006. Presentation Title: How Phytochemicals Maneuver Antitoxic and Anticancer signals in vivo.
3rd Intl. Symp. on Natural Antioxidants: Molecular Mechanisms and Health Effects, Shanghai, China, June 2005. Presentation Title: How Natural Antioxidants Propagate Anti-Cell Death Message to Normal Cells and Pro-Cell Death Message to Cancer Cells In Vivo?
Worldnutra-2004 meeting held in San Francisco, CA (Nov, 2004). Title: Antitoxic Properties of Polyphenolic Phytochemicals in vivo.
228th Am. Chem. Soc. meeting held in Philadelphia (Aug 2004). Title:“Molecular Regulation of Antiapoptotic and Antinecrotic Pathways by Citrus Bioflavonoids”.
UGC Visiting Lecture Series–Ravishankar University, Raipur, India, 2003.
Served as a judge for the “Young Investigator Award”, Society of Free Radical Biology & Medicine, Seattle, WA (Nov, 2003).
Int. Conference on Food Factors & Antioxidants meeting held in Tokyo, Japan (Dec, 2003). Presentation Title: Oxidative Stress is the Master Operator of Drug & Chemically-Induced Programmed & Unprogrammed Cell Death: Implications of Natural Antioxidants In Vivo.
University of Dortmund: Leibniz-Institute for Working Environment and Human Factors (IfADo), Dortmund, Germany, 2003.
Society of Free Radical Research, Asia, International Congress held in Seoul, Korea, Nov 2003. Tentative Ttile: “Drug and Chemically Induced Free Radical-Mediated Patterns of Target Organ Cell Death In Vivo”
Society of Free Radical Research, Europe, International Congress held in Ioannina, Greece, June-2003. Title: “Oxidative Stress Orchestrates Both Apoptotic & Necrotic Cell Death In Vivo: A New Molecular Toxicology Perspective”.
World APOPTOSIS Congress-2003, International Meeting held at the European Convention Center, Luxemberg, Jan-2003. Session’s Title: Pharmacology of Apoptosis. Presentation Title: “Lessons Learned from Drug and Chemically Induced Apoptotic Death in the Liver and Kidneys In Vivo”.
39th Annual Meeting of Am. Coll. of Nutrition, Albuquerque, NM, from Oct 1-4, 1998. Sympo. Title: Oxidative Stress & Apoptosis: Cancer Signaling Mechanisms.
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#1. Acetaminophen-Induced Liver Damage May Be Thwarted By Grape Seed Extract
http://www.pslgroup.com/dg/6C046.htm
#2. Acetaminophen Overpowers Some Cell-Protecting Genes
http://www.newswise.com/articles/acetaminophen-overpowers-some-cell-protecting-genes
http://www.toxicology.org/ai/ce/cecourse02.asp#pm10
#3. Another ground-breaking first-time observation–How NSAIDs cause apoptosis in kidneys?
http://www.brooklyn.liu.edu/wn/2002/24.html
#4. Society of Toxicology–Dr. Ray received Lifetime Achievement award–
http://www.toxicology.org/ai/pub/SP08/SP08_Scholarly_Achievement_Award.asp
#5. General and Applied Toxicology-By Bryan Ballantyne–Wiley
http://www.wiley.com/WileyCDA/WileyTitle/productCd-0470723270,descCd-tableOfContents.html [Chap-11]
#6. Desi Talk-Dr. Ray wins Highest scholastic honor of Long Island University system–’Lifetime Scholarly Award’–
http://www.desitalk.com/blog/labels/Robert%20Domingo.html
#6. Antitoxic properties of phytochemicals unveiled–
A. http://www.ascp.com/publications/tcp/1998/aug/healthtrends.shtml
http://www.npicenter.com/anm/templates/newsATemp.aspx?articleid=10188&zoneid=3
B. Ingredient in Turmeric Powder Can Thwart Drug-induced Liver Injury, Says Long Island University Pharmacy Professor Sidhartha Ray (FASEB-ASPET’07)
C. http://www.oupcanada.com/catalog/9780841239579.html
#7. International Congress in cardiology, Shanghai, China Dec 5-7, 2009.
http://www.bitlifesciences.com/icc2009/Program.asp [See program tack-1-1; 2-9]
#8. Dr. Ray’s commentary–Cancer Biology & Therapy–2008-
A. http://www.landesbioscience.com/journals/cbt/article/5797
B. http://www.fasebj.org/cgi/content/meeting_abstract/21/6/A810-a
#9. High School intern from Dr. Ray’s lab is a Intel semifinalist–joins Harvard University’08
http://stuyspectator.com/2008/02/15/11-stuyvesant-students-are-named-intel-finalists-and-semifinalists-at-four-stuyvesant-has-most-finalists-in-nation/
1. M. D. Anderson Cancer Research Center, TX, 1988.
2. Univ. of Miss. Medical Center, Jackson, MS, 1989.
3. Miss. Academy of Sciences, Jackson, MS, 1988 and 1989.
4. Univ. of New Mexico Coll. of Pharmacy, ALBQ, NM, 1989, 1990, 1991; P & G Co, Cincinnati, OH, 1990.
5. Rutgers University, EOHSI, Busch Campus, NJ. 1991, 1993.
6. Albert Einstein School of Medicine, New York, 1992; & Procter & Gamble, Cincinnati, Ohio, 1991, 1992.
7. Purdue University, West Lafayette, IN, 1992; Richardson Vicks R&D, Connecticut, 1993.
8. Natl. Center for Toxicological Res. (NCTR), Jefferson, AR, 1993/ Sandoz Pharmaceuticals, NJ, 1993.
9. National Cancer Institute, Frederick, MD, 1993; Ciba-Geigy Pharmaceuticals, NJ, 1993.
10. Medical Coll. of Virginia, Dept. of Pathology, Opening Grand Rounds, Jan 1994.
11. Creighton University College of Pharmacy, Toxicology Program, Omaha, NE, Spring-1995.
12. University of Iowa, College of Veterinary Medicine, Toxicology Program, Ames, IA. Spring-1995.
13. University of Missouri, Colombia, MO. Spring-1995.
14. University of Sciences at Philadelphia (PCPS), October, 2002.
15. Cornell University’s Graduate Program in Molecular & Env. Toxicology, (Ithaca, NY), November, 2002.
16. European Convention Center, Luxembourg, Jan 31, 2003.
17. Institute of ArbeitPhysiologie/MaxPlank Institute, Dortmund,Germany, Feb, 2003.
18. Dept. of Biology, Long Island University, Brooklyn, NY, April-2003.
19. Division of Biological Sciences, Ravishankar University, Raipur, India, August-2003.
20. Division of Molecular Biology, College of Pharmacy, Seoul National Univ., Seoul, S. Korea-Nov-2003.
21. Univ. of Colorado Health Sciences Center, College of Pharmacy, Sept-2004.
22. Wayne State University, Eugene & Applebaum Pharm. Sciences Program, Detroit, MI, Oct-2004.
23. Division of Biochemistry & Molecular Biology, Univ. of Windsor, Windsor, Canada, Oct-2004.
24. R & D Institute of Basic science Research, ChoSeon Pharma, South Korea, 2006.
2010
Lahoti T and Ray SD. ACUTE DOXORUBICIN (DXR)-INDUCED NEPHROTOXICITY INVOLVES MASSIVE OXIDATIVE STRESS AND AN ORGANIZED PERTURBATION OF MITOCHONDRIA-CENTRIC PRO- AND ANTI-APOPTOTIC GENES. [Accepted for presentation at the 2010 Society of Toxicology meetings to be held at the Salt Lake City Convention center, UT, 2010]
2009
Ray SD. Natural Antioxidants: Magic Bullets of the New Millenium for Hepatorenal Disorders. [Speaker]Presented at the 1st International Congress in Cardiology held at the Evergreen Convention Center, Shanghai, Dec 5-7, 2009.
Ray SD. Oxidative Stress and Cyt C Release: Crossroads of Cell Death via Mitochondria? [Speaker] Presented at the 1st International Congress in Cardiology held at the Evergreen Convention Center, Shanghai, Dec 5-7, 2009.
Shah, K, Parmar M and Ray SD. Ros-mediated oxidative stress influence anti-apoptotic genes and cyt c release in hyperglycemic mouse kidneys to initiate late nephropathic complications. Free Rad. Biol. Med. 47(1): pp. S87 (#223) [Presented at the Society of Free Radical Biology & Medicine meetings held at San Francisco, Nov, 2009]
Kohodos I and Ray SD. Exposure to a proanthocyanidin mixture signficantly reduces dimethylnitrosamine (dmn) ? Induced nephrocarcinogenesis in vivo. The Toxicologist 108(1):163 (Abst# 788). [Presented at the Society of Toxicology meetings held at the Baltimore convention center, March 2008]
2008
Bhatt S, Patel C and Ray SD. Differential Expression of Pro-Apoptotic and Anti-Apoptotic Genes During Diclofenac-Induced Oxidative Stress-Mediated Nephrotoxicity In Vivo. FASEB Journal, 22: 917.9 [Presented at the Experimental Biology (FASEB) meetings, San Diego, CA, 2008]
Parekh J, Sengupta A, and Ray SD. Effects of Structurally and Functionally Diverse Group of Phytochemicals on Aniline Hydroxylation (CYP2E1) of Control and Acetone-Induced Rat Liver Microsomes. FASEB Journal, Vol. 22: 1137.3 [Presented at the Experimental Biol. meetings (FASEB), San Diego, CA, 2008]
Patel C, Bhatt S, and Ray SD. Differential Expression Of Pro- and Antiapoptotic Genes Under the Influence Of Oxidative Stress During CCl4-Medaited Liver Injury in Mice. FASEB Journal, Vol. 22: 1140.3 [Presented at the Experimental Biol. meetings (FASEB), San Diego, CA, 2008]
Parmar M, Imail S and Ray SD. A Triple Bioflavonoid Mixture Modulates Pro- and Anti-Apoptotic Gene Expression During Streptozocin (STZ)-Induced Oxidative Stress in the Mouse Liver. The Toxicologist, Vol 97(1): (Abst#769) [Soc. of Toxicology meetings, Seattle, WA, 2008]
2007
Ray, S. D., Bulku, E., Zinkovsky, D., Parmar, M., Zinkovsky, D., Syed, I., Patel, C., Bhatt, S., Hackman, R. M. and Stohs, S. J. Dietary supplement Thermoplus® reduces the level of oxidative stress and stabilizes the genomic integrity in the liver and kidneys of Fisher 344 rats. Journal of the American Coll. of Nutrition, Vol. 26 (5): Pp. 497 (Abst # 72 ), 2007. [American College of Nutrition Annual meeting held in Orlando, FL, Sept 27-30, 2007]
Bulku, E., Rathod, J., Ismail, S., Parmar, M. and Ray, S. D. Antiapoptotic and Antinecrotic Properties of Bioflavonoids Curcumin and Rutin. Am. J. of Pharma. Edu. 71 (3) Article 60, 2007. [AACP Annual meeting held in Orlando, FL]
Rathod, J., Ismail, S., Parmar, M. and Ray, S. D. Modulation of matrix metallo proteases (MMPs) and MDM2 during acute dimethylnitrosamine (DMN)-induced nephrotoxicity in mice. The FASEB Journal. 21:730.2, 2007. [Exptl. Biology 2007 meeting held at the Washington DC; ASPET best poster award competition]
Ismail, S., Rathod, J., Parmar, M. and Ray, S. D. Modulation of expression of matrix metallo proteinases (MMPs -9, -10, & -12) during dimetyl nitrosamine (DMN)-induced liver cell death. Society of Toxicology meetings, Charlotte, NC, The oxicologist, Vol 96(1): 158 (Abst#769), 2007. [Society of Toxicology meetings, Charlotte, NC]
Ray, S. D., Parmar, M., Zinkovsky, D., Syed, I., Rathod, J., Shah, K., Hackman, R. M. and Stohs, S. J. Eight weeks exposure effects of a novel dietary supplement- thermoplus on serum biochemistry and histopathology of vital target organs of fisher rats. The Toxicologist, Vol 96(1): 298 (Abst#1442), 2007 [Society of Toxicology meetings, Charlotte, NC]
2006
S. D. Ray. “How Antitoxic and Anticancer signals Maneuver Programmed and Unprogrammed Cell Death In Vivo? Proceedings of the Apoptosis Congress: Cell Signaling Meetings, Editor: Marc Diderich, Luxembourg, 2006.
S. D. Ray, N. Patel, N. Shah, A. Nagori, A. Nqvi, and S. J. Stohs. Long-term exposure effects of a novel phytochemical-nutraceutical mixture (metabolic nutrition system-platinum) on serum biochemistry and histopathology of seven vital target organs of B6C3F1 mice. The Toxicologist, Vol. 90, Abst# 497, 2006. [Society of Toxicology meetings, San Diego, CA].
N. Patel and S. D. Ray. Silymarin pre-exposure modulates oxidative stress and bcl-xl expression in the liver and prevents doxorubicin-induced apoptotic and necrotic cell deaths. The Toxicologist, Vol. 90, Abst# 1979, 2006. [Society of Toxicology meetings, San Diego, CA].
E. Bulku, D. Zinkovsky, N. Patel and S. D. Ray. Curcumin pre-exposure in vivo prevents acetaminophen-induced apoptotic and necrotic cell deaths in the liver. FASEB JOURNAL 20 (5): A1144-A1144, Part 2, Mar 7, 2006. [Experimental Biology meetings, San Francisco, CA]
Elida Bulku, Jasmine Rathod, Ismail Syed, Daniel Zinkovsky, and S. D. Ray. Exposure to curcumin and citrus bioflavonoids prevent acetaminophen-induced programmed and unprogrammed cell deaths in the liver. Proceedings of the Gordon Research Conference, Meeting held at the Bryant University, Smithfield, VT; July 31st thru August 4, 2006.
2005
Ray, S. D., S. Stohs and G. B.. Corcoran. Activation of endonuclease, or caspase-activated DNAse (CAD), as a marker of apoptosis rather than necrosis in drug- or chemical-induced oncosis in vivo. The Toxicologist, Vol. 64, Abst# 2301, 2005.
Ray, S. D., A. Nagori; A. Naqvi; N. Shah, N. Patel and S. Stohs. Four week exposure to a novel nutritional mixture containing a series of polyphenolic phytochemicals antagonizes acetaminophen-induced hepatotoxicity in vivo. The Toxicologist, Vol. 64, Abst# 1410, 2005.
Ray, S. D., Hackman, R. M. and Stohs, S. J. Exposure to an ephedra and caffeine containing metabolic nutrition system for 8 months does not alter organ histopathology or serum chemistry of B6C3F1 mice. Journal of the American Coll. of Nutrition (Proceedings of ACN meeting, 2003).
2004
Patel, C. P., Raje, R. and Ray, S. D. Acute ethanol pre-exposure sensitizes liver and kidneys to furosemide-induced apoptotic and necrotic cell deaths by selectively influencing oxidative stress and genomic DNA fragmentation in vivo. The Toxicologist Vol. 73, S-1, 2004.
Phadke, S., Patel, C. and Ray, S. D. Liver cell death after acetaminophen (AP) overdose: apoptosis or oncotic necrosis? Toxicological Sciences Vol. 73, S-1, 2004.
Ray, S. D., R. Hackman and S. Stohs. Exposure for one year to a metabolic nutrition system containing ephedra and caffeine does not alter serum chemistry profile or target organ histopathology of B6C3F1 mice. Toxicological Sciences Vol. 73, S-1, 2004.
Ray, S. D. Antitoxic properties of polyphenolic phytochemicals in vivo. Symposium Speaker, Worldnutra Congress, San Francisco, CA. Proc. Of Worldnutra Congress, 2004. [Invited Speaker]
Ray, S. D. Molecular regulation of antiapoptotic and antinecrotic pathways by citrus bioflavonoids. AMERICAN CHEMICAL SOCIETY 228: U71-U71 132-AGFD, Part 1, AUG 22, 2004. [Invited Speaker]
2003
Ray, S. D. Drug and Chemically Induced Free Radical-Mediated Patterns of Target Organ Cell Death In Vivo. Proc. Soc. of Free Radical Research, Seoul, South Korea, 2003.
Ray, S. D. Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo. Int. Congress on Food factors, Tokyo, 2003.
Ray, S. D. Oxidative stress orchestrates both apoptosis & necrosis in vivo: A new perspective from molecular toxicology. Free Rad. Res. Vol. 37, (suppl.), pp. 29, 2003.
Ray, S. D., S. Gross, A. Chou, C. Brucculeri, D. Bagchi and S. Stohs. Mechanisms of Cell Death after Acetaminophen overdose: Apoptosis or Oncotic Necrosis? Experimental Biology-2003; Late Breaking Abst. session, San Diego, CA.
Phadke, S., Raje, R. R. and Ray, S. D. Acute ethanol (EtOH) exposure in vivo potentiates acetaminophen (AAP)-induced hepatocellular apoptosis by modulating oxidative stress and expression of bcl-XL and p53 genes in the liver. The Toxicologist 72(1): 361 (#1752), 2003. [*Phadke: SOT National award winner]
Stohs, S., Gross, S., Patel, C., Hackman, R. and Ray, S. D. In vivo exposure to an ephedra containing metabolic nutrition system does not alter serum biochemistry and histopathology of seven vital target organs of B6C3F1 mice. The Toxicologist 72(1): 255 (#1243), 2003.
2002
Rotollo, J. A. and Ray, S. D. Streptozotocin (STZ)-induced hyperglycemia differentially modulates acetaminophen (AAP)-induced hepatic expression of cytokine levels and apoptotic cell death. Toxicological Scs. 60(1): 377, 2002. [* J. Rotollo: SOT National award winner]
Ray, S. D. et al. Reversal of acetaminophen (AAP) and thioacetamide (TAM)-induced Caspase-Activated DNAse (CAD) and oxidative stress-mediated apoptotic and necrotic liver cell deaths by momordica charantia fruits extracts (bioflavonoids). Toxicological Scs. 60(1): 377, 2002.
2001
Ray, S. D., Lee, H. Y., Khantsis, I., Markovics, E., Phadke, S., Mohammad, S. and R. R. Raje. Alloxan and streptozotocin-induced diabetes potentiates furosemide-induced liver-injury and liver cell apoptosis in vivo. Toxicological Scs. 60(1): 377, 2001.
Ray, S. D., Parikh, H., Ali, S. and Bagchi, D. IH636 Grape Seed Proanthocyanidin Extract (GSPE) exposure significantly attenuates dimethylnitrosamine-induced liver cancer and mortality in ICR mice. Proc. Am. Assoc. Can. Res. 41(1): 460 (#2928), 2000. [H.Parikh received Award; InterHealth National Press Release]
2000
Ray, S. D., Balasubramanian, G., Raje, R. R., Reid, V. E., Reddy, C.S. and Bagchi, D. Doxorubicin-induced hepatotoxicity may involve apoptotic cell death by modulating expression of bcl-XL and p53. Toxicological Scs. 4(1):100 (#530), 2000. [G. Bala received SOT National Travel Award]
Parikh, H., Bagchi, D. and Ray, S. D. Effects of long term chronic exposure of IH636 novel grape seed proanthocyanidin extract (GSPE) on multiple target organs in mice. The FASEB J. 14(8): A1560, 2000.
Bagchi, D., Hickey, E., Parikh, H. and Ray, S. D. In Vivo IH636 Grape Seed Proanthocyanidin Extract (GSPE) exposure inhibits mouse liver microsomal CYP4502E1-dependent aniline hydroxylation in vitro. Toxicological Scs. 4(1):100 (#468), 2000.
Hickey, E. J., Reid, V. E., Raje, R. R. and Ray, S. D. Diclofenac-induced nephrotoxicity may involve oxidative stress and massive genomic DNA fragmentation in vivo. Toxicological Scs. 4(1):118 (#556), 2000. [Hickey received SOT National Travel Award; Long Island University Press Release]
Raje, R. R., Hickey, E. J., Reid, V. E. and Ray, S. D. Salicylic acid and chloroform-induced nephrotoxicities may involve genomic DNA fragmentation and cell death by apoptosis. Toxicological Scs. 4(1):118 (#556), 2000.
Ray, S. D., Hickey, E. and Bagchi, D. A novel Grape Seed Proanthocyanidin Extract (GSPE) protects multiple target organ toxicities induced by amiodarone (Lung), dimethylnitrosamine (Spleen), CdCl2 (Kidney) and MOCAP (Brain). FASEB J. 13(4): A187, 2000.
1999
Hickey, E., Parikh, H., Bagchi, D. and Ray, S. D. IH636 Grape Seed Proanthocyanidin Extract inhibits cytochrome P450-IIE1 dependent aniline hydroxylation in induced and uninduced rat liver microsomes. J. Am. Coll. Nutr. 18(5): 533 (#50), 1999.
Ray, S. D., Balasubramanian, G., Khander, A., Reddy, C. and Bagchi, D. Poly (ADP-Ribose) polymerase modulators 4-aminobenzamide (AB) and nicotinamide (NICO) protect against acetaminophen (AAP)-induced hepatotoxicity in mice by influencing expression of bcl-XL and p53. Toxicological Scs. 48(1S): 91 (#425), 1999.
1998
Wong, V., Fu, K., Kohanchi, B., Bagchi, D and Ray, S. D. Antioxidant grape seed extract (GSPE) and a DNA repair modulator 3-aminobenzamide (3-AB) protects doxorubicin (DOX)-induced cardiotoxicity in vivo. Toxicological Scs. 48(1S): 156 (#731), 1998. [V. Wong: Received E.Merck/W.Virnia Univ. Undergrad Pharm. award]
Ray, S. D., Patel, D., Wong, V., Fu, K., Rinkovsky, A. and Bagchi, D. Effect of a novel IH636 grape seed proanthocyanidin extract on acetaminophen-induced nephrotoxicity. 39th Annual Meeting of the American College of Nutrition [INVITED PRESENTATION], 1998.
Ray, S. D., Kumar, M. A. and Bagchi, D. In Vivo abrogation of acetaminophen-induced hepatic genomic DNA fragmentation and apoptotic cell death by a novel grape seed proanthocyanidin extract GSPE. The FASEB J. 12(5), Pp. A779 #4516, 1998. [*Above minisymposium presentation was chosen by FASEB National Program Committee for Press release]
Ray, S. D. Modulation of expression of Bcl-2, Bcl-XL and Bcl-XS during acetaminophen induced hepatocellular apoptosis, 1998. Toxicological Scs. 42 (1S), Pp.190.
1997
Strika, S.1, Dobrogowska, A2, Khander, A. and Ray, S. D. Furosemide induces apoptosis in the liver and kidneys in vivo. The Toxicological Scs. 42(1S), Pp 357, 1997. [1&2: Received E.Merck/W.Virnia Univ. Undergrad Pharm. award]
Ray, S. D. Does ethanol potentiate acetaminophen-induced hepatocellular apoptosis? Fund. Appl. Toxicol. 36 (1), Pp. 247, 1997.
Manolas, T., Wattamwar, A. and Ray, S. D. Induction of hepatocellular apoptosis by various alcohols in normal and Spontaneously Hypertensive-Stroke Prone rats. Fund. Appl. Toxicol. (The Toxicologist) 36 (1), Pp. 247, 1997. [T. Manolas received E.Merck/W.Virnia Univ. Undergrad award winner]
1996
Ray, S. D. Munoz, R., and Kraner, J. C. 3-Aminobenzamide, a modulator of apoptosis and necrosis induced by acetaminophen does not interfere woth p450IIE1 activity in vivo or in vitro. Fund. Appl. Toxicol. 30 (1), Pp. 71, 1996.
Dhruva, D., Sharma, S., Shleyfer, L., Raje, R. R. and Ray, S. D. Acetaminophen induced hepatocellular apoptosis in vivo: Role of Ca2+ -activated nitric oxide pathway in the absence of bcl-2 expression. Fund. Appl. Toxicol. 30 (1), Pp. 165, 1996. [Dhruva : SOT Travel Award winner]
Dhruva, D. and Ray, S. D. Role of nitric oxide in acetaminophen-induced apoptosis and necrosis and its modulation by 3-aminobenzamide. J. Clinical Toxicology 34(5), Pp 575, 1996. [*Above work received American Academy of Clinical Toxicol. National Res. Award]
Tran, M., Stohs, S., Newton, S., Bagchi, D., Tang, L. and Ray, S. D. Cadmium and chromium induced oxidative stress and programmed cell death in cultured J774A.1 macrophage cells. Fund. Appl. Toxicol. 30 (1), Pp. 167, 1995.
1995
Ray, S. D. and R. R. Raje. Acetaminophen-induced hepatocellular apoptosis in vivo shows signs of loss of mitochondrial volume regulation. Fund. Appl. Toxicol. (The Toxicologist) 15 (1): Pp. 133, 1995.
*Yahya, S. M., Ray, S. D. and Raje, R. R. Abrogation of acetaminophen induced hepato- and nephrotoxicity by 3-aminobenzamide, A DNA repair modulator. Fund. Appl. Toxicol. (The Toxicologist) 15 (1): Pp. 133, 1995. [*SOT Award winner]
1994
Ray, S. D., Mumaw, V.R., Lippman, R., Fraiss, M.W. Acetaminophen-induced apoptosis and necrosis: In Vivo protection by cholesteryl hemisuccinate pretreatment. The Toxicologist 15 (1), Pp. 187, 1994.
Mumaw, V.R., Ray, S. D., and Corcoran, G.B. Dimethylnitrosamine-induced DNA fragmentation and toxicity in mouse liver, spleen, and kidney. The Toxicologist 14 (1), Pp. 298, 1994.
Fariss, M.W., Lippman, H.R., Ray, S. D., and Smith, J.D. Characterization of cholesteryl hemisuccinate protection against CCl4-induced hepatotoxicity. The Toxicologist 14 (1), Pp. 329, 1994.
1992
Corcoran, G.B., Yorkin, R.D. and Ray, S. D. Calmodulin and calcium channel antagonists inhibit acetaminophen-induced DNA fragmentation and hepatotoxicity in mice. The Toxicologist 12(1): 131, 1992.
Burchiel, S.W., Davis, D.P., Ray, S. D., Barton, S. and Corcoran, G.B. Induction of apoptosis-like cell death by 7,12-Dimethylbenz(A)anthracene (DMBA) in the A20.1 murine B- lymphoma cell line. The Toxicologist 12(1): 341, 1992.
1991
Ray, S. D., Kamendulis, L., Shen, W., Corcoran, G.B. Acetaminophen-induced DNA fragmentation and cell death studied in vitro in cultured mouse hepatocytes. The Toxicologist 11(1): 67, 1991.
Corcoran, G.B., Ray, S. D., Sorge, C.L. and Kamendulis. DNA fragmentatio and increase in nuclear Ca2+ precede dimethylnitrosamine induced hepatic necrosis in mice. The Toxicologist 11(1): 102, 1991.
Kamendulis, L., Shen, W., Ray, S. D. and Corcoran, G.B. DNA fragmentation precedes (CH3)2nitrosamine cytotoxicity in cultured mouse hepatocytes. The Toxicologist 11(1): 254, 1991. [*Above work received SOT National ward]
Burchiel, S.W., Davis, D., Ray, S. D. Thilstead, J.P. and Corcoran, G.B. DNA fragmentation and cell death induced by DMBA in lymphoid and non lymphoid organs of B6C3F1 mice. The Toxicologist 11(1): 269, 1991.
1990
Corcoran, G.B., Ray, S. D., Kamendulis, L., and Kazemi, S. Effects of Ca2+-endonuclease and DNA repair inhibitors on hepatic necrosis induced by dimethylnitrosamine. FASEB J. 5: A1563, 1990.
Kraner, J., Lasker, J., Ray, S. D., Mouck, M. and Raucy, J.L. Induction of P450IIE1 by acetone in culture rabbit hepatocytes involves increased protein synthesis. FASEB J. 5: 6635, A1515. 1990.
Ray, S. D., Cai, Z. and Mehendale, H.M. Paradoxical toxicity of CCl4 in isolated hepatocytes from chlordecone, phenobarbital and mirex pretreated rats. The Toxicologist 10(1): 53, 1990.
Corcoran, G.B., Ray, S. D., Sorge, C.L., Braun, E., Tavacoli, A. and Raucy, J.L. Nuclear Ca2+ accumulation and massive DNA fragmentation precede aetaminophen-induced liver-injury in mice. The Toxicologist 10(1): 294, 1990.
Ji, S., Ray, S. D., Jung, K.H. and Boyaesky, A.B. The isolated perfused rat liver as an experimental model for vascular toxicity. Toxicologist 10(1): 60, 1990.
Kraner, J., Corcoran, G.B., Ray, S. D., Lasker, J. and Raucy, J.L. P450IIE1 Enzyme expression in isolated and cultured hepatocytes. The Toxicologist 10(1): 126, 1990. [*This work received Molecular Biology Specialty Section award]
1989
*Ray, S. D. and Mehendale, H.M. Suppression of cell division by carbon tetrachloride in Reuber hepatoma cells pre-exposed to chlordecone. The Toxicologist 9: 68, 1989. [*This work was chosen by the SOT Program Committee for Discussion session]
*Ray, S. D. and Mehendale, H.M. Potentiation of carbon tetrachloride hepatotoxicity and lethality by various alcohols. The Toxicologist 9(1): 59, 1989. [*Above work was chosen by the SOT Prog. Com. for Discussion session]
Ray, S. D. and Mehendale, H.M. Influence of phenobarbitol, mirex and chlordecone on the effect of carbon tetrachloride on Reuber hepatoma cell growth. FASEB J. 2(4) . 1989.
1988
Ray, S. D., Esterline, RL and Ji, S. Cytrochrome P450-independent mechanism of alchol-poteniated acetaminophen hepatotoxicity. The Toxicologist. 8 (1) 130. 1988.
Ray, S. D., Esterline, R. L. and Ji, S. Reversible and Irreversible components of acetaminophen-induced “Slow Inhibition of hepatic respiration” in livers from rats acutely pretreated with ethanol. FASEB J 2(4): 802, 1988.
Ji, S., Ray, S. D., Esterline, R. L. and Laskin, D. “Endocrinoimmunotoxicology ” of acetaminophen. FASEB J 2(6): A1680, 1988.
1987
Ray, S. D., Lee, P. Y. and Ji, S. Modulation of acetaminophen Hepatotoxicity in rats by endocrine status.The Toxicologist 7(1): 137, 1987.
1986
Ji, S., Ray, S. D., Pilaro, A. and Laskin, D. Evidence for polymorphonuclear leukocyte involvement in acetaminophen hepatotoxicity. Toxicologist 6(1) ,187. 1986.
Ray, S. D. and Ji, S. Hypophysis-mediated effects of alcohol on peroxidase activity of rat liver and ovaries. The Toxicologist 6 (1 ),187, 1986.
Ray, S. D., Esterline, R.L. and Ji, S. Inhibition of acetaminophen-induced liver injury by glucose mannitol or ethanol: Evidence that glucose is an endogenous free radical scavenger. Fed. Proc. 45 (3) : 702, 1986.
Laskin, D., Ray, S. D., Pilaro A. and Ji, S. Hypophysis and Granulocyte involvement in alcohol potentiation of acetaminophen hepatotoxicity. Fed. Proc. 45 (3): 701, 1986.
Ray, S. D. and Ji, S. Extracellular Ca2+-dependent and independent mechanisms of acetaminophen hepatotoxicity. The Toxicologist 6 (1 ),187, 1986.
1985
Ray, S.D. and Ji, S. Differential action of ethanol and acetaminophen in inducing cell injury: A biochemical study. Fed. Proc. 44 (5) :1485, 1985.
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