Posted on Jul 04, 2009 under Publications & Presentations |
1. M. D. Anderson Cancer Research Center, TX, 1988.
2. Univ. of Miss. Medical Center, Jackson, MS, 1989.
3. Miss. Academy of Sciences, Jackson, MS, 1988 and 1989.
4. Univ. of New Mexico Coll. of Pharmacy, ALBQ, NM, 1989, 1990, 1991; P & G Co, Cincinnati, OH, 1990.
5. Rutgers University, EOHSI, Busch Campus, NJ. 1991, 1993.
6. Albert Einstein School of Medicine, New York, 1992; & Procter & Gamble, Cincinnati, Ohio, 1991, 1992.
7. Purdue University, West Lafayette, IN, 1992; Richardson Vicks R&D, Connecticut, 1993.
8. Natl. Center for Toxicological Res. (NCTR), Jefferson, AR, 1993/ Sandoz Pharmaceuticals, NJ, 1993.
9. National Cancer Institute, Frederick, MD, 1993; Ciba-Geigy Pharmaceuticals, NJ, 1993.
10. Medical Coll. of Virginia, Dept. of Pathology, Opening Grand Rounds, Jan 1994.
11. Creighton University College of Pharmacy, Toxicology Program, Omaha, NE, Spring-1995.
12. University of Iowa, College of Veterinary Medicine, Toxicology Program, Ames, IA. Spring-1995.
13. University of Missouri, Colombia, MO. Spring-1995.
14. University of Sciences at Philadelphia (PCPS), October, 2002.
15. Cornell University’s Graduate Program in Molecular & Env. Toxicology, (Ithaca, NY), November, 2002.
16. European Convention Center, Luxembourg, Jan 31, 2003.
17. Institute of ArbeitPhysiologie/MaxPlank Institute, Dortmund,Germany, Feb, 2003.
18. Dept. of Biology, Long Island University, Brooklyn, NY, April-2003.
19. Division of Biological Sciences, Ravishankar University, Raipur, India, August-2003.
20. Division of Molecular Biology, College of Pharmacy, Seoul National Univ., Seoul, S. Korea-Nov-2003.
21. Univ. of Colorado Health Sciences Center, College of Pharmacy, Sept-2004.
22. Wayne State University, Eugene & Applebaum Pharm. Sciences Program, Detroit, MI, Oct-2004.
23. Division of Biochemistry & Molecular Biology, Univ. of Windsor, Windsor, Canada, Oct-2004.
24. R & D Institute of Basic science Research, ChoSeon Pharma, South Korea, 2006.
Posted on Jul 04, 2009 under Publications & Presentations |
2010
Lahoti T and Ray SD. ACUTE DOXORUBICIN (DXR)-INDUCED NEPHROTOXICITY INVOLVES MASSIVE OXIDATIVE STRESS AND AN ORGANIZED PERTURBATION OF MITOCHONDRIA-CENTRIC PRO- AND ANTI-APOPTOTIC GENES. [Accepted for presentation at the 2010 Society of Toxicology meetings to be held at the Salt Lake City Convention center, UT, 2010]
2009
Ray SD. Natural Antioxidants: Magic Bullets of the New Millenium for Hepatorenal Disorders. [Speaker]Presented at the 1st International Congress in Cardiology held at the Evergreen Convention Center, Shanghai, Dec 5-7, 2009.
Ray SD. Oxidative Stress and Cyt C Release: Crossroads of Cell Death via Mitochondria? [Speaker] Presented at the 1st International Congress in Cardiology held at the Evergreen Convention Center, Shanghai, Dec 5-7, 2009.
Shah, K, Parmar M and Ray SD. Ros-mediated oxidative stress influence anti-apoptotic genes and cyt c release in hyperglycemic mouse kidneys to initiate late nephropathic complications. Free Rad. Biol. Med. 47(1): pp. S87 (#223) [Presented at the Society of Free Radical Biology & Medicine meetings held at San Francisco, Nov, 2009]
Kohodos I and Ray SD. Exposure to a proanthocyanidin mixture signficantly reduces dimethylnitrosamine (dmn) ? Induced nephrocarcinogenesis in vivo. The Toxicologist 108(1):163 (Abst# 788). [Presented at the Society of Toxicology meetings held at the Baltimore convention center, March 2008]
2008
Bhatt S, Patel C and Ray SD. Differential Expression of Pro-Apoptotic and Anti-Apoptotic Genes During Diclofenac-Induced Oxidative Stress-Mediated Nephrotoxicity In Vivo. FASEB Journal, 22: 917.9 [Presented at the Experimental Biology (FASEB) meetings, San Diego, CA, 2008]
Parekh J, Sengupta A, and Ray SD. Effects of Structurally and Functionally Diverse Group of Phytochemicals on Aniline Hydroxylation (CYP2E1) of Control and Acetone-Induced Rat Liver Microsomes. FASEB Journal, Vol. 22: 1137.3 [Presented at the Experimental Biol. meetings (FASEB), San Diego, CA, 2008]
Patel C, Bhatt S, and Ray SD. Differential Expression Of Pro- and Antiapoptotic Genes Under the Influence Of Oxidative Stress During CCl4-Medaited Liver Injury in Mice. FASEB Journal, Vol. 22: 1140.3 [Presented at the Experimental Biol. meetings (FASEB), San Diego, CA, 2008]
Parmar M, Imail S and Ray SD. A Triple Bioflavonoid Mixture Modulates Pro- and Anti-Apoptotic Gene Expression During Streptozocin (STZ)-Induced Oxidative Stress in the Mouse Liver. The Toxicologist, Vol 97(1): (Abst#769) [Soc. of Toxicology meetings, Seattle, WA, 2008]
2007
Ray, S. D., Bulku, E., Zinkovsky, D., Parmar, M., Zinkovsky, D., Syed, I., Patel, C., Bhatt, S., Hackman, R. M. and Stohs, S. J. Dietary supplement Thermoplus® reduces the level of oxidative stress and stabilizes the genomic integrity in the liver and kidneys of Fisher 344 rats. Journal of the American Coll. of Nutrition, Vol. 26 (5): Pp. 497 (Abst # 72 ), 2007. [American College of Nutrition Annual meeting held in Orlando, FL, Sept 27-30, 2007]
Bulku, E., Rathod, J., Ismail, S., Parmar, M. and Ray, S. D. Antiapoptotic and Antinecrotic Properties of Bioflavonoids Curcumin and Rutin. Am. J. of Pharma. Edu. 71 (3) Article 60, 2007. [AACP Annual meeting held in Orlando, FL]
Rathod, J., Ismail, S., Parmar, M. and Ray, S. D. Modulation of matrix metallo proteases (MMPs) and MDM2 during acute dimethylnitrosamine (DMN)-induced nephrotoxicity in mice. The FASEB Journal. 21:730.2, 2007. [Exptl. Biology 2007 meeting held at the Washington DC; ASPET best poster award competition]
Ismail, S., Rathod, J., Parmar, M. and Ray, S. D. Modulation of expression of matrix metallo proteinases (MMPs -9, -10, & -12) during dimetyl nitrosamine (DMN)-induced liver cell death. Society of Toxicology meetings, Charlotte, NC, The oxicologist, Vol 96(1): 158 (Abst#769), 2007. [Society of Toxicology meetings, Charlotte, NC]
Ray, S. D., Parmar, M., Zinkovsky, D., Syed, I., Rathod, J., Shah, K., Hackman, R. M. and Stohs, S. J. Eight weeks exposure effects of a novel dietary supplement- thermoplus on serum biochemistry and histopathology of vital target organs of fisher rats. The Toxicologist, Vol 96(1): 298 (Abst#1442), 2007 [Society of Toxicology meetings, Charlotte, NC]
2006
S. D. Ray. “How Antitoxic and Anticancer signals Maneuver Programmed and Unprogrammed Cell Death In Vivo? Proceedings of the Apoptosis Congress: Cell Signaling Meetings, Editor: Marc Diderich, Luxembourg, 2006.
S. D. Ray, N. Patel, N. Shah, A. Nagori, A. Nqvi, and S. J. Stohs. Long-term exposure effects of a novel phytochemical-nutraceutical mixture (metabolic nutrition system-platinum) on serum biochemistry and histopathology of seven vital target organs of B6C3F1 mice. The Toxicologist, Vol. 90, Abst# 497, 2006. [Society of Toxicology meetings, San Diego, CA].
N. Patel and S. D. Ray. Silymarin pre-exposure modulates oxidative stress and bcl-xl expression in the liver and prevents doxorubicin-induced apoptotic and necrotic cell deaths. The Toxicologist, Vol. 90, Abst# 1979, 2006. [Society of Toxicology meetings, San Diego, CA].
E. Bulku, D. Zinkovsky, N. Patel and S. D. Ray. Curcumin pre-exposure in vivo prevents acetaminophen-induced apoptotic and necrotic cell deaths in the liver. FASEB JOURNAL 20 (5): A1144-A1144, Part 2, Mar 7, 2006. [Experimental Biology meetings, San Francisco, CA]
Elida Bulku, Jasmine Rathod, Ismail Syed, Daniel Zinkovsky, and S. D. Ray. Exposure to curcumin and citrus bioflavonoids prevent acetaminophen-induced programmed and unprogrammed cell deaths in the liver. Proceedings of the Gordon Research Conference, Meeting held at the Bryant University, Smithfield, VT; July 31st thru August 4, 2006.
2005
Ray, S. D., S. Stohs and G. B.. Corcoran. Activation of endonuclease, or caspase-activated DNAse (CAD), as a marker of apoptosis rather than necrosis in drug- or chemical-induced oncosis in vivo. The Toxicologist, Vol. 64, Abst# 2301, 2005.
Ray, S. D., A. Nagori; A. Naqvi; N. Shah, N. Patel and S. Stohs. Four week exposure to a novel nutritional mixture containing a series of polyphenolic phytochemicals antagonizes acetaminophen-induced hepatotoxicity in vivo. The Toxicologist, Vol. 64, Abst# 1410, 2005.
Ray, S. D., Hackman, R. M. and Stohs, S. J. Exposure to an ephedra and caffeine containing metabolic nutrition system for 8 months does not alter organ histopathology or serum chemistry of B6C3F1 mice. Journal of the American Coll. of Nutrition (Proceedings of ACN meeting, 2003).
2004
Patel, C. P., Raje, R. and Ray, S. D. Acute ethanol pre-exposure sensitizes liver and kidneys to furosemide-induced apoptotic and necrotic cell deaths by selectively influencing oxidative stress and genomic DNA fragmentation in vivo. The Toxicologist Vol. 73, S-1, 2004.
Phadke, S., Patel, C. and Ray, S. D. Liver cell death after acetaminophen (AP) overdose: apoptosis or oncotic necrosis? Toxicological Sciences Vol. 73, S-1, 2004.
Ray, S. D., R. Hackman and S. Stohs. Exposure for one year to a metabolic nutrition system containing ephedra and caffeine does not alter serum chemistry profile or target organ histopathology of B6C3F1 mice. Toxicological Sciences Vol. 73, S-1, 2004.
Ray, S. D. Antitoxic properties of polyphenolic phytochemicals in vivo. Symposium Speaker, Worldnutra Congress, San Francisco, CA. Proc. Of Worldnutra Congress, 2004. [Invited Speaker]
Ray, S. D. Molecular regulation of antiapoptotic and antinecrotic pathways by citrus bioflavonoids. AMERICAN CHEMICAL SOCIETY 228: U71-U71 132-AGFD, Part 1, AUG 22, 2004. [Invited Speaker]
2003
Ray, S. D. Drug and Chemically Induced Free Radical-Mediated Patterns of Target Organ Cell Death In Vivo. Proc. Soc. of Free Radical Research, Seoul, South Korea, 2003.
Ray, S. D. Oxidative stress is the master operator of drug and chemically-induced programmed and unprogrammed cell death: Implications of natural antioxidants in vivo. Int. Congress on Food factors, Tokyo, 2003.
Ray, S. D. Oxidative stress orchestrates both apoptosis & necrosis in vivo: A new perspective from molecular toxicology. Free Rad. Res. Vol. 37, (suppl.), pp. 29, 2003.
Ray, S. D., S. Gross, A. Chou, C. Brucculeri, D. Bagchi and S. Stohs. Mechanisms of Cell Death after Acetaminophen overdose: Apoptosis or Oncotic Necrosis? Experimental Biology-2003; Late Breaking Abst. session, San Diego, CA.
Phadke, S., Raje, R. R. and Ray, S. D. Acute ethanol (EtOH) exposure in vivo potentiates acetaminophen (AAP)-induced hepatocellular apoptosis by modulating oxidative stress and expression of bcl-XL and p53 genes in the liver. The Toxicologist 72(1): 361 (#1752), 2003. [*Phadke: SOT National award winner]
Stohs, S., Gross, S., Patel, C., Hackman, R. and Ray, S. D. In vivo exposure to an ephedra containing metabolic nutrition system does not alter serum biochemistry and histopathology of seven vital target organs of B6C3F1 mice. The Toxicologist 72(1): 255 (#1243), 2003.
2002
Rotollo, J. A. and Ray, S. D. Streptozotocin (STZ)-induced hyperglycemia differentially modulates acetaminophen (AAP)-induced hepatic expression of cytokine levels and apoptotic cell death. Toxicological Scs. 60(1): 377, 2002. [* J. Rotollo: SOT National award winner]
Ray, S. D. et al. Reversal of acetaminophen (AAP) and thioacetamide (TAM)-induced Caspase-Activated DNAse (CAD) and oxidative stress-mediated apoptotic and necrotic liver cell deaths by momordica charantia fruits extracts (bioflavonoids). Toxicological Scs. 60(1): 377, 2002.
2001
Ray, S. D., Lee, H. Y., Khantsis, I., Markovics, E., Phadke, S., Mohammad, S. and R. R. Raje. Alloxan and streptozotocin-induced diabetes potentiates furosemide-induced liver-injury and liver cell apoptosis in vivo. Toxicological Scs. 60(1): 377, 2001.
Ray, S. D., Parikh, H., Ali, S. and Bagchi, D. IH636 Grape Seed Proanthocyanidin Extract (GSPE) exposure significantly attenuates dimethylnitrosamine-induced liver cancer and mortality in ICR mice. Proc. Am. Assoc. Can. Res. 41(1): 460 (#2928), 2000. [H.Parikh received Award; InterHealth National Press Release]
2000
Ray, S. D., Balasubramanian, G., Raje, R. R., Reid, V. E., Reddy, C.S. and Bagchi, D. Doxorubicin-induced hepatotoxicity may involve apoptotic cell death by modulating expression of bcl-XL and p53. Toxicological Scs. 4(1):100 (#530), 2000. [G. Bala received SOT National Travel Award]
Parikh, H., Bagchi, D. and Ray, S. D. Effects of long term chronic exposure of IH636 novel grape seed proanthocyanidin extract (GSPE) on multiple target organs in mice. The FASEB J. 14(8): A1560, 2000.
Bagchi, D., Hickey, E., Parikh, H. and Ray, S. D. In Vivo IH636 Grape Seed Proanthocyanidin Extract (GSPE) exposure inhibits mouse liver microsomal CYP4502E1-dependent aniline hydroxylation in vitro. Toxicological Scs. 4(1):100 (#468), 2000.
Hickey, E. J., Reid, V. E., Raje, R. R. and Ray, S. D. Diclofenac-induced nephrotoxicity may involve oxidative stress and massive genomic DNA fragmentation in vivo. Toxicological Scs. 4(1):118 (#556), 2000. [Hickey received SOT National Travel Award; Long Island University Press Release]
Raje, R. R., Hickey, E. J., Reid, V. E. and Ray, S. D. Salicylic acid and chloroform-induced nephrotoxicities may involve genomic DNA fragmentation and cell death by apoptosis. Toxicological Scs. 4(1):118 (#556), 2000.
Ray, S. D., Hickey, E. and Bagchi, D. A novel Grape Seed Proanthocyanidin Extract (GSPE) protects multiple target organ toxicities induced by amiodarone (Lung), dimethylnitrosamine (Spleen), CdCl2 (Kidney) and MOCAP (Brain). FASEB J. 13(4): A187, 2000.
1999
Hickey, E., Parikh, H., Bagchi, D. and Ray, S. D. IH636 Grape Seed Proanthocyanidin Extract inhibits cytochrome P450-IIE1 dependent aniline hydroxylation in induced and uninduced rat liver microsomes. J. Am. Coll. Nutr. 18(5): 533 (#50), 1999.
Ray, S. D., Balasubramanian, G., Khander, A., Reddy, C. and Bagchi, D. Poly (ADP-Ribose) polymerase modulators 4-aminobenzamide (AB) and nicotinamide (NICO) protect against acetaminophen (AAP)-induced hepatotoxicity in mice by influencing expression of bcl-XL and p53. Toxicological Scs. 48(1S): 91 (#425), 1999.
1998
Wong, V., Fu, K., Kohanchi, B., Bagchi, D and Ray, S. D. Antioxidant grape seed extract (GSPE) and a DNA repair modulator 3-aminobenzamide (3-AB) protects doxorubicin (DOX)-induced cardiotoxicity in vivo. Toxicological Scs. 48(1S): 156 (#731), 1998. [V. Wong: Received E.Merck/W.Virnia Univ. Undergrad Pharm. award]
Ray, S. D., Patel, D., Wong, V., Fu, K., Rinkovsky, A. and Bagchi, D. Effect of a novel IH636 grape seed proanthocyanidin extract on acetaminophen-induced nephrotoxicity. 39th Annual Meeting of the American College of Nutrition [INVITED PRESENTATION], 1998.
Ray, S. D., Kumar, M. A. and Bagchi, D. In Vivo abrogation of acetaminophen-induced hepatic genomic DNA fragmentation and apoptotic cell death by a novel grape seed proanthocyanidin extract GSPE. The FASEB J. 12(5), Pp. A779 #4516, 1998. [*Above minisymposium presentation was chosen by FASEB National Program Committee for Press release]
Ray, S. D. Modulation of expression of Bcl-2, Bcl-XL and Bcl-XS during acetaminophen induced hepatocellular apoptosis, 1998. Toxicological Scs. 42 (1S), Pp.190.
1997
Strika, S.1, Dobrogowska, A2, Khander, A. and Ray, S. D. Furosemide induces apoptosis in the liver and kidneys in vivo. The Toxicological Scs. 42(1S), Pp 357, 1997. [1&2: Received E.Merck/W.Virnia Univ. Undergrad Pharm. award]
Ray, S. D. Does ethanol potentiate acetaminophen-induced hepatocellular apoptosis? Fund. Appl. Toxicol. 36 (1), Pp. 247, 1997.
Manolas, T., Wattamwar, A. and Ray, S. D. Induction of hepatocellular apoptosis by various alcohols in normal and Spontaneously Hypertensive-Stroke Prone rats. Fund. Appl. Toxicol. (The Toxicologist) 36 (1), Pp. 247, 1997. [T. Manolas received E.Merck/W.Virnia Univ. Undergrad award winner]
1996
Ray, S. D. Munoz, R., and Kraner, J. C. 3-Aminobenzamide, a modulator of apoptosis and necrosis induced by acetaminophen does not interfere woth p450IIE1 activity in vivo or in vitro. Fund. Appl. Toxicol. 30 (1), Pp. 71, 1996.
Dhruva, D., Sharma, S., Shleyfer, L., Raje, R. R. and Ray, S. D. Acetaminophen induced hepatocellular apoptosis in vivo: Role of Ca2+ -activated nitric oxide pathway in the absence of bcl-2 expression. Fund. Appl. Toxicol. 30 (1), Pp. 165, 1996. [Dhruva : SOT Travel Award winner]
Dhruva, D. and Ray, S. D. Role of nitric oxide in acetaminophen-induced apoptosis and necrosis and its modulation by 3-aminobenzamide. J. Clinical Toxicology 34(5), Pp 575, 1996. [*Above work received American Academy of Clinical Toxicol. National Res. Award]
Tran, M., Stohs, S., Newton, S., Bagchi, D., Tang, L. and Ray, S. D. Cadmium and chromium induced oxidative stress and programmed cell death in cultured J774A.1 macrophage cells. Fund. Appl. Toxicol. 30 (1), Pp. 167, 1995.
1995
Ray, S. D. and R. R. Raje. Acetaminophen-induced hepatocellular apoptosis in vivo shows signs of loss of mitochondrial volume regulation. Fund. Appl. Toxicol. (The Toxicologist) 15 (1): Pp. 133, 1995.
*Yahya, S. M., Ray, S. D. and Raje, R. R. Abrogation of acetaminophen induced hepato- and nephrotoxicity by 3-aminobenzamide, A DNA repair modulator. Fund. Appl. Toxicol. (The Toxicologist) 15 (1): Pp. 133, 1995. [*SOT Award winner]
1994
Ray, S. D., Mumaw, V.R., Lippman, R., Fraiss, M.W. Acetaminophen-induced apoptosis and necrosis: In Vivo protection by cholesteryl hemisuccinate pretreatment. The Toxicologist 15 (1), Pp. 187, 1994.
Mumaw, V.R., Ray, S. D., and Corcoran, G.B. Dimethylnitrosamine-induced DNA fragmentation and toxicity in mouse liver, spleen, and kidney. The Toxicologist 14 (1), Pp. 298, 1994.
Fariss, M.W., Lippman, H.R., Ray, S. D., and Smith, J.D. Characterization of cholesteryl hemisuccinate protection against CCl4-induced hepatotoxicity. The Toxicologist 14 (1), Pp. 329, 1994.
1992
Corcoran, G.B., Yorkin, R.D. and Ray, S. D. Calmodulin and calcium channel antagonists inhibit acetaminophen-induced DNA fragmentation and hepatotoxicity in mice. The Toxicologist 12(1): 131, 1992.
Burchiel, S.W., Davis, D.P., Ray, S. D., Barton, S. and Corcoran, G.B. Induction of apoptosis-like cell death by 7,12-Dimethylbenz(A)anthracene (DMBA) in the A20.1 murine B- lymphoma cell line. The Toxicologist 12(1): 341, 1992.
1991
Ray, S. D., Kamendulis, L., Shen, W., Corcoran, G.B. Acetaminophen-induced DNA fragmentation and cell death studied in vitro in cultured mouse hepatocytes. The Toxicologist 11(1): 67, 1991.
Corcoran, G.B., Ray, S. D., Sorge, C.L. and Kamendulis. DNA fragmentatio and increase in nuclear Ca2+ precede dimethylnitrosamine induced hepatic necrosis in mice. The Toxicologist 11(1): 102, 1991.
Kamendulis, L., Shen, W., Ray, S. D. and Corcoran, G.B. DNA fragmentation precedes (CH3)2nitrosamine cytotoxicity in cultured mouse hepatocytes. The Toxicologist 11(1): 254, 1991. [*Above work received SOT National ward]
Burchiel, S.W., Davis, D., Ray, S. D. Thilstead, J.P. and Corcoran, G.B. DNA fragmentation and cell death induced by DMBA in lymphoid and non lymphoid organs of B6C3F1 mice. The Toxicologist 11(1): 269, 1991.
1990
Corcoran, G.B., Ray, S. D., Kamendulis, L., and Kazemi, S. Effects of Ca2+-endonuclease and DNA repair inhibitors on hepatic necrosis induced by dimethylnitrosamine. FASEB J. 5: A1563, 1990.
Kraner, J., Lasker, J., Ray, S. D., Mouck, M. and Raucy, J.L. Induction of P450IIE1 by acetone in culture rabbit hepatocytes involves increased protein synthesis. FASEB J. 5: 6635, A1515. 1990.
Ray, S. D., Cai, Z. and Mehendale, H.M. Paradoxical toxicity of CCl4 in isolated hepatocytes from chlordecone, phenobarbital and mirex pretreated rats. The Toxicologist 10(1): 53, 1990.
Corcoran, G.B., Ray, S. D., Sorge, C.L., Braun, E., Tavacoli, A. and Raucy, J.L. Nuclear Ca2+ accumulation and massive DNA fragmentation precede aetaminophen-induced liver-injury in mice. The Toxicologist 10(1): 294, 1990.
Ji, S., Ray, S. D., Jung, K.H. and Boyaesky, A.B. The isolated perfused rat liver as an experimental model for vascular toxicity. Toxicologist 10(1): 60, 1990.
Kraner, J., Corcoran, G.B., Ray, S. D., Lasker, J. and Raucy, J.L. P450IIE1 Enzyme expression in isolated and cultured hepatocytes. The Toxicologist 10(1): 126, 1990. [*This work received Molecular Biology Specialty Section award]
1989
*Ray, S. D. and Mehendale, H.M. Suppression of cell division by carbon tetrachloride in Reuber hepatoma cells pre-exposed to chlordecone. The Toxicologist 9: 68, 1989. [*This work was chosen by the SOT Program Committee for Discussion session]
*Ray, S. D. and Mehendale, H.M. Potentiation of carbon tetrachloride hepatotoxicity and lethality by various alcohols. The Toxicologist 9(1): 59, 1989. [*Above work was chosen by the SOT Prog. Com. for Discussion session]
Ray, S. D. and Mehendale, H.M. Influence of phenobarbitol, mirex and chlordecone on the effect of carbon tetrachloride on Reuber hepatoma cell growth. FASEB J. 2(4) . 1989.
1988
Ray, S. D., Esterline, RL and Ji, S. Cytrochrome P450-independent mechanism of alchol-poteniated acetaminophen hepatotoxicity. The Toxicologist. 8 (1) 130. 1988.
Ray, S. D., Esterline, R. L. and Ji, S. Reversible and Irreversible components of acetaminophen-induced “Slow Inhibition of hepatic respiration” in livers from rats acutely pretreated with ethanol. FASEB J 2(4): 802, 1988.
Ji, S., Ray, S. D., Esterline, R. L. and Laskin, D. “Endocrinoimmunotoxicology ” of acetaminophen. FASEB J 2(6): A1680, 1988.
1987
Ray, S. D., Lee, P. Y. and Ji, S. Modulation of acetaminophen Hepatotoxicity in rats by endocrine status.The Toxicologist 7(1): 137, 1987.
1986
Ji, S., Ray, S. D., Pilaro, A. and Laskin, D. Evidence for polymorphonuclear leukocyte involvement in acetaminophen hepatotoxicity. Toxicologist 6(1) ,187. 1986.
Ray, S. D. and Ji, S. Hypophysis-mediated effects of alcohol on peroxidase activity of rat liver and ovaries. The Toxicologist 6 (1 ),187, 1986.
Ray, S. D., Esterline, R.L. and Ji, S. Inhibition of acetaminophen-induced liver injury by glucose mannitol or ethanol: Evidence that glucose is an endogenous free radical scavenger. Fed. Proc. 45 (3) : 702, 1986.
Laskin, D., Ray, S. D., Pilaro A. and Ji, S. Hypophysis and Granulocyte involvement in alcohol potentiation of acetaminophen hepatotoxicity. Fed. Proc. 45 (3): 701, 1986.
Ray, S. D. and Ji, S. Extracellular Ca2+-dependent and independent mechanisms of acetaminophen hepatotoxicity. The Toxicologist 6 (1 ),187, 1986.
1985
Ray, S.D. and Ji, S. Differential action of ethanol and acetaminophen in inducing cell injury: A biochemical study. Fed. Proc. 44 (5) :1485, 1985.
Posted on Jul 03, 2009 under Publications & Presentations |
Reviews and Book Chapters:
1. Ray, S. D. and Corcoran, G. B. "Apoptosis and Cell Death" in Bryan Ballantyne’s 3rd Editionof ‘General and Applied Toxicology’, Pp. 248-312, [ISBN# 978-0-470-72327-2], JONH WYLIE Publishing, UK, Dec 2009.
2. Ray SD, Zinkovsky D, Bulku E and Patil BS. "Prevention of Drug-Induced Programmed and Unprogrammed Cell Death by Citrus Flavonoids." Potential Health Benefits of Citrus, Eds. Bhimanagouda S. Patil, Nancy D. Turner, Edward G. Miller and Jennifer S. Brodbelt. Washington DC, American Chemical Society, Pp. 144-160 (ISBN13: 9780841239579/ ISBN10: 0841239576), 2006.
3. Principal author of the Review Chapters "APOPTOSIS" in ‘Encyclopedia of Toxicology’, Ed. Philip Wexler, 2nd Eds, Vol-I, Pp. 153-178, Elsevier Science Publishing. Also the Principal author of the review article on "Dimethylnitrosamine" in ‘Encyclopedia of Toxicology’, 2005.
4. Principal author of "Apoptosis and Cell Death", Vol. I, Chapter-9, Pp. 175-213, in Bryan Ballantyne’s 2nd Edition of ‘General and Applied Toxicology’, McMillan Publishing, 1999.
5. Ray, S. D. et. al. Roles of Polyphenols, Flavonoids, and Oligomeric Proanthocyanidins in Cancer Chemoprevention’ in ‘Phytopharmaceuticals in cancer chemoprevention’, Eds. H. G. Preuss and D. Bagchi, CRC Press, Pp. 311-348, [ISBN#08493-1560-3], 2005.
6. Ray, S.D. and Corcoran, G.B. Damage to the nucleus and acute cell death produced by alkylating hepatotoxins. In “Molecular Theories of Cell Life and Death”, S.Ji. Ed., Rutgers Univ. Press, NJ. Chapter -10, Pp. 384 – 400, 1991. (Citation for the following data obtained through Scopus, SCI & Google Scholar)
PEER REVIEWED PUBLICATIONS:
Bulku E, Zinkovsky D, Patel P, Javia V, Lahoti T, Khodos I, Stohs SJ and Ray SD. A novel dietary supplement containing multiple phytochemicals and vitamins elevates hepatorenal and cardiac antioxidant enzymes in the absence of significant serum chemistry and genomic changes. Oxidative Medicine & Cellular Longevity 3(2):129-144, 2010.
Patel N, Joseph C, Corcoran GB and Ray SD. Silymarin Modulates Doxorubicin-Induced Oxidative Stress, Bcl-XL and p53 Expression while Preventing Apoptotic and Necrotic Cell Death in the Liver. Toxicology & Applied Pharmacology 245(2): 143-152, 2010.
*Yung E, MD; Yarmush JM; Weinberg J, MD; Schianodicola, JJ, MD; and Ray SD, Ph.D. Comparison of the Potency of Lidocaine and Chloroprocaine in Sciatic Nerve Block in Sprague-Dawley Rats. Pharmacology 83(6):356-359, 2009. [*NY Methodist Hospital Collaboration, Brooklyn, NY]
*Yung E, MD; Lahoti T, MS; Soheila J, MD; Weinberg J, MD; Yarmush J, MD; Schianodicola, JJ, MD; and Ray SD, Ph.D. Bicarbonate Plus Epinephrine Shortens the Onset and Prolongs the Duration of Sciatic Block Using Chloroprocaine Followed by Bupivacaine in Sprague-Dawley Rats. Regional Anesthesia and Pain Medicine, 34(3): 196 – 200, 2009. [*NY Methodist Hospital Collaboration, Brooklyn, NY]
Ray, S. Synergy of Pancratistatin and Tamoxifen in inducing apoptosis in breast cancer cells. Cancer Biology & Therapy, Volume: 7 | Issue: 3, 2008 (Invited Commentary)
Ray SD, Parmar M, Rathod J, Ismail S, Zinkovsky D, Bulku E, Gigliotti J, Hackman RM and Stohs S J. Long Term Exposure Effect of a Unique Metabolic Nutrition System Containing a Diverse Group Of Phytochemicals on Serum Chemistry and Genomic and Non-Genomic Changes in the Liver of Female B6C3F1 Mice. Phytotherapy Research 22(4): 458-471, 2008. (Times cited: 
Ray SD, Patel N, Nagori A, Naqvi A and Stohs SJ. Four week exposure to a novel nutritional mixture containing a series of polyphenolic phytochemicals antagonizes acetaminophen-induced programmed and unprogrammed cell death in the liver in vivo. Molecular and Cellular Biochemistry. 293(1-2):119-36, 2006. (Times cited-10)
Ray S, Phadke S, Patel C, Hackman RM, Stohs S. Short-term and long-term in vivo exposure to an ephedra- and caffeine-containing metabolic nutrition system does not induce cardiotoxicity in B6C3F1 mice. Archives of Toxicol. 79(6): 330-340, 2005. (Times cited-10)
Ray SD, Parikh H and Bagchi D. Long-Term grape seed proanthocyanidin extract exposure to B6C3F1 mice significantly attenuates dimethylnitrosamine-induced liver tumor induction and mortality by differentially modulating programmed and unprogrammed cell deaths. Mutation Research 579 (1-2): 81-106, 2005. (Times cited-15)
Ray, SD et al. Oxidative Stress is the Master Operator of Drug & Chemically-Induced Programmed & Unprogrammed Cell Death: Implications of Natural Antioxidants In Vivo. Biofactors, 21(1-4):223-232, 2004. (Times cited-15)
Ray SD. Oxidative stress orchestrates both apoptosis & necrosis in vivo: A new perspective from molecular toxicology. Proc. Of the Meeting of the Soc. Free Rad. Res, Ed. D. Galaris, Pp. 45-53, 2004. (Times cited-10)
Bagchi D, Sen CK, Ray SD, Das DK, Bagchi M, Preuss HG and Vinson JA. Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutatation Research 523-524:87-97, 2003. (Times cited: 170)
Bagchi D, Ray SD, Bagchi M, Preuss HG, and Stohs, SJ. Mechanistic pathways of antioxidant cytoprotection by a novel IH636 grape seed proanthocyanidin extract. Indian J. Exp. Biol. 40(6):717-726, 2002. (Times cited-15)
Bagchi D, Bagchi M, Stohs SJ, Ray SD, Sen CK and Preuss HG. Cellular protection with proanthocyanidins derived from grape seeds. Ann New York Acad Sciences 957:260-70; 2002. (Times cited: 130)
Ray SD, Balasubramanian G, Reddy CS and Bagchi D. Ca2+-Calmodulin Antagonist Chlorpromazine and Poly (ADP-Ribose) Polymerase Modulators 4-Aminobenzamide and Nicotinamide Influence Hepatic Expression of Bcl-XL and P53 and Protect against acetaminophen-induced programmed and unprogrammed cell death in mice. Free Radical Biology & Medicine, 31(3): 277-291, 2001. (Times cited: 37)
Hickey EJ, Raje RR, Reid VE, Gross SM, and Ray SD Diclofenac-Induced in vivo nephrotoxicity may involve oxidative stress mediated massive genomic DNA fragmentation and apoptotic cell death. Free Radical Biology & Medicine, 31(2): 139-152, 2001. (Times cited: 51)
Ray SD, Parikh H, Hickey E, Bagchi M, and Bagchi D. Differential effects of IH636 grape seed proanthocyanidin extract and a DNA repair modulator 4-aminobenzamide on liver microsomal CYP-4502E1 dependent aniline hydroxylation. Molecular & Cellular Biochemistry, 218: 27-33, 2001. (Times cited: 18)
Bagchi M, Balmoori J, Ye X, Ray SD and Stohs SJ. Protective effect of melatonin on naphthalene-induced oxidative stress and DNA damage in cultures macrophage J774A.1 cells. Molecular & Cellular Biochemistry, 221: 49-55, 2001. (Times cited-15)
Ray S, Bagchi D, Lim PM, Bagchi M, Gross SM, Kothari SC, Preuss HG, Stohs SJ. Acute and long-term safety evaluation of a novel IH636 grape seed proanthocyanidin extract. Res Commun Mol Pathol Pharmacol., 109(3- 4):165-97, 2001. (Times cited-40)
Ray, S. D. and Jena, N. A hepatotoxic dose of acetaminophen modulates expression of bcl-2, bcl-XL, and bcl-Xs during apoptotic and necrotic death of mouse liver cells in vivo. Archives of Toxicology, 73: 594-606, 2000. (Times cited: 55)
Ray, S. D., Patel, D., Wong, V., Rinkovsky, A., Bagchi, M., Raje, R. R. and Bagchi, D. Unique organoprotective properties of a novel a novel IH636 grape seed proanthocyanidin extract on cadmium chloride-induced nephrotoxicity, dimethylnitrosamine-induced spleenotoxicity, and mocap-induced neurotoxicity in mice. Res. Commu. Mol. Pathol. & Pharmacol., 107: 105-128, 2000. (Times cited-19)
Ray, S. D., Patel, D., Wong, V. and Bagchi, D. In vivo protection of DNA damage associated apoptotic and necrotic cell deaths during acetaminophen-induced nephrotoxicity, amiodarone-induced lung toxicity and doxorubicin-induced cardiotoxicity by a novel IH636 grape seed proanthocyanidin extract. Res. Commu. Mol. Pathol. & Pharmacol., 107: 137-166, 2000. (Times cited: 32)
Bagchi, D., Ray, S. D., Patel, D. and Bagchi, M. Protection against drug- and chemically-induced multiorgan toxicity by a novel IH636 grape seed proanthocyanidin extract. Drugs Exptl. Clin. Res., 27: 3-15, 2000. (Times cited: 30)
Bagchi, D ., Bagchi, M., Stohs, S., Das, D. K., Ray, S. D., Kuszynski, C. A., Joshi, S. and Preuss, H. G. Free radicals and grape seed proanthocyanidin extract: importance in human health and disease prevention. Toxicology 148: 187-197, 2000. (Times cited: 430)
Ray, S.D., Kumar, A. and Bagchi, D. A novel proanthocyanidin IH636 extract increases in vivo bcl-XL expression and prevents acetaminophen-induced programmed and unprogrammed cell death in mouse liver. Arch. Biochem. Biophys., 369: 42-58, 1999. (Times cited: 61)
Babar, A., Ray, S. D., Patel, N. K., Plakoginnis, F. M. and Goginani, P. In Vitro release and diffusion studies of promethazine-HCl from polymeric dermatological bases using cellular membrane and hairless mouse skin. Drug Deliv. & Ind. Pharam., 25:235-240, 1999. (Times cited: 10)
Bagchi, M., Balmoori, J., Bagchi, D., Ray, S. D., Kuszynski, C. and Stohs, S. J. Smokeless tobacco, oxidative stress, apoptosis, and antioxidants in human oral keratinocytes. Free Radi. Biol. and Med., 26:992-1000, 1999. (Times cited: 60)
Bagchi, D., Vuchetich, P. J., Bagchi, M., Tran, M. X., Krohn, R. L., Ray, S. D. and Stohs, S. J. Protective effects of Zinc salts on TPA-induced hepatic and brain lipid peroxidation, glutathione depletion, DNA damage, and peritoneal macrophage activation in mice. General Pharmacology, 30: 43-50, 1998. (Times cited: 45)
Bagchi, D., Tran, M. X., Newton, S., Bagchi, M., Ray, S. D., Kuszynski, C. A. and Stohs, S. J. Chromium and cadmium induced oxidative stress and apoptosis in cultured J774.1 macrophage cells. In Vitro and Molecular Toxicology, 11: 171-181, 1998. (Times cited: 10)
Bagchi, D., Carryl, O. R., Tran, M. X., Bagchi, M., Vuchetich, P. J., Krohn, R. L., Ray, S. D. and Stohs, S. J. Protection against chemically-induced oxidative gastrointestinal tissue injury in rats by bismuth salts. Digestive Diseases Sciences, 42: 1890-1900, 1997. (Times cited: 15)
Fariss, M. W., Lippman, H. R., Mumaw, V. R. and Ray, S. D. Cholesteryl hemisuccinate treatment protects rodents from the toxic effects of acetaminophen, adriamycin, carbontetrachloride, chloroform and galactosamine. Toxicology Letters, 90: 133-144, 1997. (Times cited-5)
Ray, S. D., Mumaw, V. R., Raje, R. R. and Fariss, M. W. Protection of acetaminophen-induced hepatocellular apoptosis and necrosis by cholesteryl hemisuccinate pretreatments. J. Pharm. Exp. Thera. 279: 1470-1483, 1996. (Times cited: 105)
Ray, S. D. and Fariss, M. W. Role of Cellular Energy status in tocopheryl hemisuccinate cytoprotection against Ethyl methane sulfonate-induced toxicity. Archives of Biochem. and Biophys., 311: 180-190, 1994. (Times cited: 35)
Fariss, M., Jhonson, S., Walton, L. P., Mumaw, V. and Ray, S. D. Tetrahydroaminoacridine-induced ribosomal changes and inhibition of protein synthesis in rat hepatocyte suspensions. Hepatology 20:240 – 246, 1994. (Times cited: 14)
Ray, S. D., Kamendulis,L, Gurule, M, Yorkin, R. and Corcoran, G.B. Ca2+ antagonists inhibit DNA fragmentation and toxic cell death induced by acetaminophen. FASEB Journal, Vol 7: 453-463. 1993. (Times cited: 156)
Kraner, J.C., Lasker, J., Corcoran, G.B., Ray, S. D. and Raucy, J.L. Elevation of P-450IIE1 by acetone in isolated rabbit hepatocytes may involve de novo m-RNA synthesis. Biochem. Pharmacol. 45 : 1483-1492, 1993. (Times cited: 25)
Burchiel, S.W., Davis, D., Ray, S. D. and Barton, S. DMBA induces programmed cell death (Apoptosis) in the A20.1 murine B-cell lymphoma. Fund. Appl. Toxicol. 21: 120-124, 1993. (Times cited-45)
Corcoran, G.B. and Ray, S. D. The role of the nucleus and other hepatocellular compartments in acute cell death produced by alkylating hepatotoxins: Contemporary Issues In Toxicology. Toxicol. Appl. Pharm. 113: 167-183, 1992. (Times cited: 60)
Ray, S.D., Sorge, C.L., Kamendulis, L. and Corcoran, G.B. Role of Ca2+-activated DNA fragmentation in DMN-induced hepatic necrosis: Effects of Ca2+ -endonuclease and poly (ADP-Ribose) polymerase inhibitors in mice. J. Pharmacol. Exp. Therapeu. 263: 387 – 394, 1992. (Times cited: 45)
Shen, W., Kamendulis, L., Ray, S. D. and Corcoran, G.B. Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Effects of endonuclease, DNA repair and glutathione depletion inhibitors on DNA fragmentation and cell death. Toxicol. Appl. Pharmacol., 112: 32 – 40, 1992. (Times cited: 64)
Burchiel, S.W., Davies, D., Ray, S. D., Thilsted, J.P. and Corcoran, G.B. DMBA-induced cytotoxicity in lymphoid and non lymphoid organs of B6C3F1 mice: Relation to cell death to intracellular calcium and DNA damage. Toxicol. Appl. Pharmacol., 113:126-132, 1992. (Times cited: 25)
Ray, S. D., Sorge, C.L., Tavacoli, A., Raucy, J.L. and Corcoran, G.B. Extensive alteration of genomic DNA and rise in nuclear Ca2+ in vivo early after hepatotoxic acetaminophen overdose in mice. In Biological Reactive Intermediates IV. Molecular & Cellular Effects and their impact on Human Health. Adv. Exp. Med. Biol., 238: 699 – 705, 1991. (Times cited: 15)
Shen, W., Kamendulis, L., Ray, S. D. and Corcoran, G.B. Acetaminophen-induced cytotoxicity in cultured mouse hepatocytes: Correlation of nuclear Ca2+ accumulation and DNA fragmentation cell death. Toxicol. Appl. Pharmacol., 111: 242-254, 1991. (Times cited: 63)
Mehendale, H.M., Ray, S. D. and Cai, Z. Paradoxical toxicity of CCl4 in isolated hepatocytes from chlordecone, phenobarbital and mirex treated rats. In Vitro Toxicol. 4: 187 – 196, 1991. (Times cited: 5)
Ray, S. D., Sorge, C.L., Raucy, J.L. and Corcoran, G.B. Early loss of large genomic DNA in vivo with accumulation of Ca2+ in the nucleus during acetaminophen induced liver injury. Tox. Appl. Pharm. 106: 346 – 51, 1990. (Times cited: 62)
Ray, S. D. and Mehendale, H. M. Potentiation of CCl4 and CHCl3 hepatotoxicity and lethality by various alcohols. Fundam. Appl. Toxicol. 15: 429 – 440, 1990. (Times cited: 24)
Mehendale, H.M. and Ray, S.D. Inhibition of cell division in hepatoma cell cultures by chlordecone and carbon tetrachloride combination. Toxicology in Vitro, 4: 179 -183, 1990. (Times cited: 20)
Esterline, R., Ray, S. D. and Ji, S. Reversible and Irreversible inhibition of hepatic mitochondrial respiration by acetaminophen and its toxic metabolite, N-acetyl-p-benzoquinoneimine (NAPQI). Biochemical. Pharmacol. 38: 2387-2390, 1989. (Times cited: 51)
Ji, S., Ray, S. D. and Esterline, R. Intracellular Dissipative Structures (IDS) as ultimate targets of chemical cytotoxicity. pp. 871-889 In Biological Reactive Intermediates III. Adv. Exp. Med. Biol. 197: 871- 889, 1986. (Times cited:
Ray, S. D. Part-I: GA, ABA, Phenol Interaction in the control of growth: Phenolic compounds as effective modulators of GA-ABA interaction in radish seedlings. Biologia Plantarum (Checzk) 28: 361- 369, 1986. (Times cited: 15)
Ray, S. D. and Laloraya, M. M. Interaction of gibberellic acid, abscisic acid, and phenolic compounds in the control hypocotyl growth of Amaranthus caudatus seedlings. Canadian J. Bot.., 62: 2047- 2052, 1984. (Times cited: 12)
Pawar, M.S., Ray, S. D. and Laloraya, M.M. Antagonistic action of phenolic compounds on abscisic acid-induced inhibition of seed germination. Beitr. Biol. Pflanzen. (W. Germany) 60: 15 – 21, 1984. (Times cited: 12)
Ray, S. D., Guru, K.N. and Laloraya, M.M. Reversal of abscisic acid-induced betacyanin systhesis by phenolic compounds in Amaranthus caudatus seedlings. Physiol. Plant. (Copenhagen) 58: 175 – 178, 1983. (Times cited: 12)
Ray, S. D., Guru, K.N. and Laloraya, M.M. Antagonistic action of phenolic compounds on Abscisic acid induced inhibition of hypocotyl growth. J. Exp. Bot. (London) 31(125):1651- 1656, 1980. (Times cited: 21)
Pal, S., Arora, B., Chhutani, P.N., Choudury, S. and Ray, S. D. Rabies virus infection in a flying fox bat, Pteropus poliocephalus. Tropical & Geographic Medicine (US) 32: 265 -267, 1980. (Times cited: 12)
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